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KIF11 - kinesin family member 11

Product
List

Gene
Details

Interaction
Network

Canonical
Pathway

Literature

Clinical Trial

Disease

Compound

Expression

Regulation

SNP

Entrez Gene Name: kinesin family member 11
Entrez GeneID: Human(3832), Mouse(16551), Rat(171304)
Synonyms: EG5, HKSP, KIF11, Kif8, Kifl1, KNSL1, TRIP5

Gene Summary

  • Human (3832): This gene encodes a motor protein that belongs to the kinesin-like protein family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis. [provided by RefSeq]
  • Rat (171304): participates in motile activities within the cell [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras

Cell Regulation

Regulates:
  • DCTN1
View all 2 in IPA
Regulated by:
  • fulvestrant
  • SMARCB1
  • methylselenic acid
View all 27 in IPA
Binds:
  • KIF11
  • THRB
  • miR-122
View all 70 in IPA
Role in cell:
  • organization
  • formation
  • quantity
View all 10 in IPA
Disease:
  • non-insulin-dependent diabetes mellitus
  • bone cancer
  • neurofibromatosis 1
View all 18 in IPA

Biological Process

blood coagulation, cell cycle, cell division, metabolic process, microtubule-based movement, mitosis, mitotic centrosome separation, mitotic spindle organization, spindle assembly involved in mitosis, spindle organization

Cellular Components

chromatin remodeling complex, cytoplasm, cytoskeleton, cytosol, kinesin complex, microtubule, spindle, spindle microtubule, spindle pole

Literature References

  • 17974955Castillo A, Morse HC, Godfrey VL, Naeem R, Justice MJ. Overexpression of eg5 causes genomic instability and tumor formation in mice.Cancer Res 2007 Nov 01;67(21):10138-47
  • 9742151Ferhat L, Cook C, Chauviere M, Harper M, Kress M, Lyons GE, Baas PW. Expression of the mitotic motor protein Eg5 in postmitotic neurons: implications for neuronal development.J Neurosci 1998 Oct 1;18(19):7822-35
  • 9235942Blangy A, Arnaud L, Nigg EA. Phosphorylation by p34cdc2 protein kinase regulates binding of the kinesin-related motor HsEg5 to the dynactin subunit p150.J Biol Chem 1997 Aug 1;272(31):19418-24
View 229 categorized literature findings and their references in IPA

Molecular Functions

ATP binding, microtubule motor activity, nucleotide binding, protein kinase binding

Pathways

Protein Domains

Motor_domain, protein kinase binding, stalk region, tail domain

Subcellular Locations

axon branches, centriole, centrosome, Cytoplasm, cytosol, lamellipodia, microtubule aster fraction, microtubule bundles, mitotic spindle, nerve ending, Nucleus, pericentrosomal region, perikaryon, postmitotic bridges, spindle pole

IPA Extras