LPAR2 - lysophosphatidic acid receptor 2
Entrez Gene Name: lysophosphatidic acid receptor 2
Entrez GeneID: Human(9170)
, Mouse(53978), Rat(498609)
, Mouse(53978), Rat(498609) Synonyms: EDG-4, FLJ93869, IPA2, LPA receptor 2, LPA2, LPA2 RECEPTOR, LPAR2, Pbx4, RGD1561336
Gene Summary
- Human (9170): This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
activation of MAPK activity, activation of phospholipase C activity, elevation of cytosolic calcium ion concentration, G-protein coupled receptor protein signaling pathway, positive regulation of MAPKKK cascade, positive regulation of Rho protein signal transduction, signal transduction
Literature References
- 17965021Lin FT, Lai YJ, Makarova N, Tigyi G, Lin WC. The Lysophosphatidic Acid 2 Receptor Mediates Down-regulation of Siva-1 to Promote Cell Survival.J Biol Chem 2007 Dec 28;282(52):37759-69
- 15728708Yun CC, Sun H, Wang D, Rusovici R, Castleberry A, Hall RA, Shim H. LPA2 receptor mediates mitogenic signals in human colon cancer cells.Am J Physiol Cell Physiol 2005 Jul 01;289(1):C2-11
- 14670967Fang X, Yu S, Bast RC, Liu S, Xu HJ, Hu SX, LaPushin R, Claret FX, Aggarwal BB, Lu Y, Mills GB. Mechanisms for Lysophosphatidic Acid-induced Cytokine Production in Ovarian Cancer Cells.J Biol Chem 2004 Mar 05;279(10):9653-61 View 301 categorized literature findings and their references in IPA
Molecular Functions
G-protein coupled receptor activity, LIM domain binding, lipid binding, lysosphingolipid and lysophosphatidic acid receptor activity, PDZ domain binding, protein binding, receptor activity, signal transducer activity
Protein Domains
G-protein coupled receptor, LIM-domain binding, lipid binding, lysosphingolipid and lysophosphatidic acid receptor, PDZ-domain binding, protein binding, tail domain
