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LPAR2 - lysophosphatidic acid receptor 2
Entrez Gene Name: lysophosphatidic acid receptor 2
Entrez GeneID: Human(9170)
, Mouse(53978), Rat(498609)
, Mouse(53978), Rat(498609) Synonyms: EDG-4, FLJ93869, IPA2, LPA receptor 2, LPA-2, LPA2 RECEPTOR, LPAR2, Pbx4, RGD1561336
Gene Summary
- Human (9170): This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
activation of MAPK activity, activation of phospholipase C activity, elevation of cytosolic calcium ion concentration, G-protein coupled receptor protein signaling pathway, positive regulation of MAPKKK cascade, positive regulation of Rho protein signal transduction, signal transduction
Cellular Components
cell surface, endocytic vesicle, integral to membrane, integral to plasma membrane, plasma membrane
Literature References
- 19293149E S, Lai YJ, Tsukahara R, Chen CS, Fujiwara Y, Yue J, Yu JH, Guo H, Kihara A, Tigyi G, Lin FT. Lysophosphatidic Acid 2 Receptor-mediated Supramolecular Complex Formation Regulates Its Antiapoptotic Effect.J Biol Chem 2009 May 22;284(21):14558-71
- 17965021Lin FT, Lai YJ, Makarova N, Tigyi G, Lin WC. The Lysophosphatidic Acid 2 Receptor Mediates Down-regulation of Siva-1 to Promote Cell Survival.J Biol Chem 2007 Dec 28;282(52):37759-69
- 15728708Yun CC, Sun H, Wang D, Rusovici R, Castleberry A, Hall RA, Shim H. LPA2 receptor mediates mitogenic signals in human colon cancer cells.Am J Physiol Cell Physiol 2005 Jul 01;289(1):C2-11
Molecular Functions
G-protein coupled receptor activity, LIM domain binding, lipid binding, lysosphingolipid and lysophosphatidic acid receptor activity, PDZ domain binding, protein binding, receptor activity, signal transducer activity
Protein Domains
7 transmembrane receptor (rhodopsin family), CXXC zinc finger, G-protein coupled receptor, LIM-domain binding, lipid binding, lysosphingolipid and lysophosphatidic acid receptor, PDZ binding motif, PDZ-domain binding, protein binding, tail domain