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CLU - clusterin
Entrez Gene Name: clusterin
Entrez GeneID: Human(1191)
, Mouse(12759), Rat(24854)
, Mouse(12759), Rat(24854) Synonyms: AAG4, AI893575, APOJ, APOLIPOPROTEIN J, CLI, CLU, CLUSTERIN, COMPLEMENT CYTOLYSIS INHIBITOR, D14Ucla3, DAG, Gp80, KUB1, MGC24903, RATTRPM2B, SGP-2, SP-40, Sugp-2, Sulfated glycoprotein 2, TRMP2, TRPM-2, TRPM2B, Trpmb
Gene Summary
- Human (1191): The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Alternate splicing results in both coding and non-coding variants.[provided by RefSeq, May 2011]
- Mouse (12759): The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. [provided by RefSeq, May 2011]
- Rat (24854): The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders.[provided by RefSeq, May 2011]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
anti-apoptosis, apoptosis, blood coagulation, cell death, cellular response to growth factor stimulus, chaperone-mediated protein folding, complement activation, complement activation, classical pathway, endocrine pancreas development, induction of apoptosis by intracellular signals, innate immune response, lipid metabolic process, multicellular organismal development, negative regulation of apoptosis, negative regulation of protein homooligomerization, neuron projection morphogenesis, platelet activation, platelet degranulation, positive regulation of apoptosis, positive regulation of cell differentiation, positive regulation of cell proliferation, positive regulation of NF-kappaB transcription factor activity, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process, protein stabilization, release of cytochrome c from mitochondria, response to misfolded protein, response to oxidative stress, response to stress, response to virus, response to wounding, reverse cholesterol transport, spermatogenesis
Cellular Components
aggresome, chromaffin granule, cytoplasm, cytoplasmic vesicle, cytosol, endoplasmic reticulum, extracellular matrix, extracellular region, extracellular space, growth cone, membrane, microsome, mitochondrial membrane, mitochondrion, neuron projection, nucleus, perinuclear region of cytoplasm, platelet alpha granule lumen, spherical high-density lipoprotein particle
Literature References
- 21460853Goetz EM, Shankar B, Zou Y, Morales JC, Luo X, Araki S, Bachoo R, Mayo LD, Boothman DA. ATM-dependent IGF-1 induction regulates secretory clusterin expression after DNA damage and in genetic instability.Oncogene 2011 Sep 01;30(35):3745-54
- 14741101DeMattos RB, Cirrito JR, Parsadanian M, May PC, O'Dell MA, Taylor JW, Harmony JA, Aronow BJ, Bales KR, Paul SM, Holtzman DM. ApoE and Clusterin Cooperatively Suppress Abeta Levels and Deposition. Evidence that ApoE Regulates Extracellular Abeta Metabolism In Vivo.Neuron 2004 Jan 22;41(2):193-202
- 18082619Lee KB, Jeon JH, Choi I, Kwon OY, Yu K, You KH. Clusterin, a novel modulator of TGF-beta signaling, is involved in Smad2/3 stability.Biochem Biophys Res Commun 2008 Feb 22;366(4):905-9
Molecular Functions
ATPase activity, misfolded protein binding, protein binding, ubiquitin protein ligase binding
Protein Domains
Clusterin, CLUSTERIN alpha chain, CLUSTERIN Beta chain, coiled-coil domain, Ku70 protein binding domain, nuclear localization sequence, protein binding, signal peptide, ubiquitin protein ligase binding
Subcellular Locations
aggresome, alpha granules, apical cell surfaces, apical compartment, apical vesicles, basement membrane, cell surface, Cytoplasm, cytosol, detergent resistant lipid raft fraction, endoplasmic reticulum, endosomes, exosomes, Extracellular Space, Golgi apparatus, granules, growth cone, lipoprotein fractions, mitochondria, neurites, Nucleus, perinuclear region, pH resistant lipid raft fraction, plasma, Plasma Membrane, secretory granules, secretory vesicles, stereocilia, vacuole