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CCL4 - chemokine (C-C motif) ligand 4
Entrez Gene Name: chemokine (C-C motif) ligand 4
Entrez GeneID: Human(6351)
, Mouse(20303), Rat(116637)
, Mouse(20303), Rat(116637) Synonyms: ACT2, AT744.1, CCL4, G-26, HC21, LAG1, MGC104418, MGC126025, MGC126026, MIP-1-BETA, MIP-1B, MIP1B1, MIP1β, SCYA2, SCYA4
Gene Summary
- Rat (116637): a cytokine that is up-regulated during the inflammatory response; may be involved in intrapulmonary recruitment of neutrophils [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
cell adhesion, cell-cell signaling, cellular component movement, chemotaxis, establishment or maintenance of cell polarity, immune response, inflammatory response, regulation of vascular permeability, response to virus, signal transduction, viral genome replication
Literature References
- 17018274Mantovani A, Balkwill F. RalB signaling: a bridge between inflammation and cancer.Cell 2006 Oct 06;127(1):42-4
- 11877481Mellor EA, Austen KF, Boyce JA. Cysteinyl leukotrienes and uridine diphosphate induce cytokine generation by human mast cells through an interleukin 4-regulated pathway that is inhibited by leukotriene receptor antagonists.J Exp Med 2002 Mar 4;195(5):583-92
- 11244051Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A. Interleukin-10 and the interleukin-10 receptor.Annu Rev Immunol 2001 Jan 01;19:683-765
Molecular Functions
chemokine activity, cytokine activity, protein binding, receptor signaling protein tyrosine kinase activity
- Differential Regulation of Cytokine Production in Intestinal Epithelial Cells by IL-17A and IL-17F
- Chemokine Signaling
- Role of IL-17F in Allergic Inflammatory Airway Diseases
- Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza
- Pathogenesis of Multiple Sclerosis
- CCR5 Signaling in Macrophages
- Differential Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL-17F
- Communication between Innate and Adaptive Immune Cells
Protein Domains
3-10 helix, chemokine, Chemokine, cytokine, dimerization domain, N-loop domain, protein binding
Subcellular Locations
cell surface, cytosol, Extracellular Space, intracellular space, membrane fraction, soluble fraction