CCL4 - chemokine (C-C motif) ligand 4
Entrez Gene Name: chemokine (C-C motif) ligand 4
Entrez GeneID: Human(6351)
, Mouse(20303), Rat(116637)
, Mouse(20303), Rat(116637) Synonyms: ACT2, AT744.1, CCL4, G-26, HC21, LAG1, MGC104418, MGC126025, MGC126026, MIP-1-BETA, MIP-1B, MIP1B1, SCYA2, SCYA4
Gene Summary
- Rat (116637): a cytokine that is up-regulated during the inflammatory response; may be involved in intrapulmonary recruitment of neutrophils [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Disease:
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Biological Process
cell adhesion, cell motion, cell-cell signaling, chemotaxis, establishment or maintenance of cell polarity, immune response, inflammatory response, regulation of vascular permeability, response to virus, signal transduction, viral genome replication
Literature References
- 11877481Mellor EA, Austen KF, Boyce JA. Cysteinyl leukotrienes and uridine diphosphate induce cytokine generation by human mast cells through an interleukin 4-regulated pathway that is inhibited by leukotriene receptor antagonists.J Exp Med 2002 Mar 4;195(5):583-92
- 11244051Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A. Interleukin-10 and the interleukin-10 receptor.Annu Rev Immunol 2001 Jan 01;19:683-765
- 10837070Sallusto F, Mackay CR, Lanzavecchia A. The role of chemokine receptors in primary, effector, and memory immune responses.Annu Rev Immunol 2000;18:593-620 View 1590 categorized literature findings and their references in IPA
Molecular Functions
chemokine activity, cytokine activity, protein binding, receptor signaling protein tyrosine kinase activity
Subcellular Locations
cell surface, cytosol, extracellular space, intracellular space, membrane fraction
