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VLDLR - very low density lipoprotein receptor
Entrez Gene Name: very low density lipoprotein receptor
Entrez GeneID: Human(7436)
, Mouse(22359), Rat(25696)
, Mouse(22359), Rat(25696) Synonyms: AA408956, AI451093, AW047288, CARMQ1, CHRMQ1, FLJ35024, VLDL RECEPTOR TYPE I, VLDLR, VLDLRCH
Gene Summary
- Human (7436): The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. This gene encodes a lipoprotein receptor that is a member of the LDLR family and plays important roles in VLDL-triglyceride metabolism and the reelin signaling pathway. Mutations in this gene cause VLDLR-associated cerebellar hypoplasia. Alternative splicing generates multiple transcript variants encoding distinct isoforms for this gene. [provided by RefSeq]
- Rat (25696): mouse homolog is a lipoprotein receptor involved in the metabolic handling of triacylglycerol [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
cell surface receptor linked signaling pathway, cellular response to glucose starvation, cellular response to hypoxia, cellular response to insulin stimulus, cellular response to interleukin-1, cellular response to lipopolysaccharide, cerebral cortex development, cholesterol metabolic process, endocytosis, heart development, lipid metabolic process, lipid transport, memory, nervous system development, positive regulation of protein kinase activity, positive regulation of protein tyrosine kinase activity, response to drug, response to hormone stimulus, response to hypoxia, response to lipopolysaccharide, response to nutrient, signal transduction, steroid metabolic process, transport, very-low-density lipoprotein particle clearance
Cellular Components
apical part of cell, cell surface, coated pit, extracellular space, integral to membrane, membrane, membrane fraction, nucleus, perinuclear region of cytoplasm, plasma membrane, very-low-density lipoprotein particle
Literature References
- 19120042Spalice A, Parisi P, Nicita F, Pizzardi G, Del Balzo F, Iannetti P. Neuronal migration disorders: clinical, neuroradiologic and genetics aspects.Acta Paediatr 2009 Mar 01;98(3):421-33
- 18039658Poirier S, Mayer G, Benjannet S, Bergeron E, Marcinkiewicz J, Nassoury N, Mayer H, Nimpf J, Prat A, Seidah NG. The Proprotein Convertase PCSK9 Induces the Degradation of Low Density Lipoprotein Receptor (LDLR) and Its Closest Family Members VLDLR and ApoER2.J Biol Chem 2008 Jan 25;283(4):2363-72
- 17452316Zhang DW, Lagace TA, Garuti R, Zhao Z, McDonald M, Horton JD, Cohen JC, Hobbs HH. Binding of Proprotein Convertase Subtilisin/Kexin Type 9 to Epidermal Growth Factor-like Repeat A of Low Density Lipoprotein Receptor Decreases Receptor Recycling and Increases Degradation.J Biol Chem 2007 Jun 22;282(25):18602-12
Molecular Functions
apolipoprotein binding, calcium ion binding, low-density lipoprotein receptor activity, protein binding, protein tyrosine kinase activator activity, receptor activity, very-low-density lipoprotein particle receptor activity
Protein Domains
cytoplasmic domain, cytosolic tail domain, ectodomain, EGF-like domain, EGF_CA, extracellular domain, LDLa, ligand binidng repeat, ligand-binding domain, low-density lipoprotein receptor, Low-density lipoprotein receptor repeat class B, protein binding, protein tyrosine kinase activator, transporter, very-low-density lipoprotein receptor
Subcellular Locations
apical compartment, cell surface, cellular membrane, Extracellular Space, membrane fraction, Nucleus, perinuclear region, Plasma Membrane, vesicles