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E2F6 - E2F transcription factor 6
Entrez Gene Name: E2F transcription factor 6
Entrez GeneID: Human(1876)
, Mouse(50496), Rat(313978)
, Mouse(50496), Rat(313978) Synonyms: AI462434, E2F6, E2F6b, EMA, MGC111545
Gene Summary
- Human (1876): This gene encodes a member of the E2F transcription factor protein family. E2F family members play a crucial role in control of the cell cycle and of the action of tumor suppressor proteins. They are also a target of the transforming proteins of small DNA tumor viruses. Many E2F proteins contain several evolutionarily conserved domains: a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. The encoded protein of this gene is atypical because it lacks the transactivation and tumor suppressor protein association domains. It contains a modular suppression domain and is an inhibitor of E2F-dependent transcription. The protein is part of a multimeric protein complex that contains a histone methyltransferase and the transcription factors Mga and Max. Multiple transcript variants have been reported for this gene, but it has not been clearly demonstrated that they encode valid isoforms. [provided by RefSeq]
- Rat (313978): mouse homolog is a transcription factor; involved in the regulation of cell cycle progression [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Disease:
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Biological Process
cell cycle, negative regulation of transcription from RNA polymerase II promoter, regulation of transcription involved in G1/S phase of mitotic cell cycle, regulation of transcription, DNA-dependent, transcription, DNA-dependent
Cellular Components
DNA replication factor A complex, MLL1 complex, nucleus, transcription factor complex
Literature References
- 11799066Weinmann AS, Yan PS, Oberley MJ, Huang TH, Farnham PJ. Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis.Genes Dev 2002 Jan 15;16(2):235-44
- 9694791Dyson N. The regulation of E2F by pRB-family proteins.Genes Dev 1998 Aug 1;12(15):2245-62
- 16189514Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M. Towards a proteome-scale map of the human protein-protein interaction network.Nature 2005 10 20;437(7062):1173-8
Molecular Functions
DNA binding, sequence-specific DNA binding transcription factor activity, transcription corepressor activity
- Breast Cancer Regulation by Stathmin1
- Role of CHK Proteins in Cell Cycle Checkpoint Control
- Role of BRCA1 in DNA Damage Response
- Glioblastoma Multiforme Signaling
- Cell Cycle: G1/S Checkpoint Regulation
- Cell Cycle Regulation by BTG Family Proteins
- Molecular Mechanisms of Cancer
- Pancreatic Adenocarcinoma Signaling
- Chronic Myeloid Leukemia Signaling
- Glioma Signaling
- Cyclins and Cell Cycle Regulation
Protein Domains
DNA binding, DNA binding domain, E2F/DP family winged-helix DNA-binding domain, leucine zipper domain, marked box, transcription co-repressor, transcription factor, transcription regulator, transcription repression domain