-
Product Directory
Custom Product
-
Services Offered
Custom Capabilities
-
SPARC - secreted protein, acidic, cysteine-rich (osteonectin)
Canonical
Pathway
Entrez Gene Name: secreted protein, acidic, cysteine-rich (osteonectin)
Entrez GeneID: Human(6678)
, Mouse(20692), Rat(24791)
, Mouse(20692), Rat(24791) Synonyms: AA517111, Basement membrane protein-40, BM-40, MGC128090, ON, OSTEONECTIN, SPARC
Gene Summary
- Human (6678): Secreted protein acidic and rich in cysteine/osteonectin/BM40, or SPARC, is a matrix-associated protein that elicits changes in cell shape, inhibits cell-cycle progression, and influences the synthesis of extracellular matrix (ECM) (Bradshaw et al., 2003 [PubMed 12721366]).[supplied by OMIM, Mar 2008]
- Rat (24791): secreted structural protein; may be a component of collagen and the extracellular matrix [RGD, Feb 2006]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
blood coagulation, cellular response to growth factor stimulus, heart development, inner ear development, lung development, ossification, platelet activation, platelet degranulation, regulation of cell proliferation, response to cadmium ion, response to calcium ion, response to cAMP, response to cytokine stimulus, response to ethanol, response to glucocorticoid stimulus, response to gravity, response to L-ascorbic acid, response to lead ion, response to lipopolysaccharide, response to peptide hormone stimulus, signal transduction, wound healing
Cellular Components
basement membrane, cytoplasm, extracellular matrix, extracellular region, extracellular space, intracellular, membrane-bounded vesicle, nucleus, platelet alpha granule lumen, proteinaceous extracellular matrix
Literature References
- 19342370Sussman AN, Sun T, Krofft RM, Durvasula RV. SPARC Accelerates Disease Progression in Experimental Crescentic Glomerulonephritis.Am J Pathol 2009 May 01;174(5):1827-36
- 9524110Gilmour DT, Lyon GJ, Carlton MB, Sanes JR, Cunningham JM, Anderson JR, Hogan BL, Evans MJ, Colledge WH. Mice deficient for the secreted glycoprotein SPARC/osteonectin/BM40 develop normally but show severe age-onset cataract formation and disruption of the lens.EMBO J 1998 Apr 1;17(7):1860-70
- 16885349Robert G, Gaggioli C, Bailet O, Chavey C, Abbe P, Aberdam E, Sabatié E, Cano A, Garcia de Herreros A, Ballotti R, Tartare-Deckert S. SPARC Represses E-Cadherin and Induces Mesenchymal Transition during Melanoma Development.Cancer Res 2006 Aug 01;66(15):7516-23
Molecular Functions
calcium ion binding, collagen binding, extracellular matrix binding, protein binding
Protein Domains
acidic domain, calcium ion binding, collagen binding, EF-Hand, extracellular domain, extracellular matrix binding, follistatin (FS) domain, Follistatin/Osteonectin-like EGF domain, KAZAL_FS, protein binding, Secreted protein acidic and rich in cysteine Ca binding region, signal peptide
Subcellular Locations
alpha granules, cell surface, Cytoplasm, cytoplasmic particles, extracellular matrix, Extracellular Space, intracellular space, membrane fraction, Nucleus, proteinaceous extracellular matrix, vesicles