TBP - TATA box binding protein
Entrez Gene Name: TATA box binding protein
Entrez GeneID: Human(6908)
, Mouse(21374), Rat(117526)
, Mouse(21374), Rat(117526) Synonyms: GTF2D, GTF2D1, MGC117320, MGC126054, MGC126055, MGC93994, SCA17, TATA BOX FACTOR, TBP, TFIID
Gene Summary
- Human (6908): Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminal. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. Mutations that expand the number of CAG repeats encoding this polyglutamine tract, and thus increase the length of the polyglutamine string, are associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. [provided by RefSeq]
- Rat (117526): mouse homolog binds to TATA box promoter element; involved in activation of eukaryotic genes [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Disease:
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Biological Process
cell death, general transcription from RNA polymerase II promoter, interspecies interaction between organisms, positive regulation of transcription, regulation of transcription, DNA-dependent, RNA elongation from RNA polymerase II promoter, spermatogenesis, transcription, transcription initiation from RNA polymerase II promoter
Cellular Components
cytoplasm, female pronucleus, male pronucleus, nucleoplasm, nucleus, pronucleus, RNA polymerase I transcription factor complex, transcription factor TFIIA complex, transcription factor TFIID complex
Literature References
- 11893333Zhao X, Herr W. A regulated two-step mechanism of TBP binding to DNA: a solvent-exposed surface of TBP inhibits TATA box recognition.Cell 2002 Mar 8;108(5):615-27
- 10921893McCulloch V, Hardin P, Peng W, Ruppert JM, Lobo-Ruppert SM. Alternatively spliced hBRF variants function at different RNA polymerase III promoters.EMBO J 2000 Aug 1;19(15):4134-43
- 16713569Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.Cell 2006 May 19;125(4):801-14 View 2294 categorized literature findings and their references in IPA
Molecular Functions
binding, DNA binding, general RNA polymerase II transcription factor activity, protein binding, RNA polymerase II transcription factor activity, transcription factor activity, transcription factor binding
Protein Domains
core domain, functional, core domain, structural, DNA binding, DNA binding domain, general RNA polymerase II transcription factor, N-terminal domain, polyglutamine repeat, protein binding, transcription factor, transcription factor binding, transcription regulator
Subcellular Locations
chromatin, chromosomes, cytoplasm, detergent-insoluble fractions, detergent-soluble fraction, nuclear fraction, nucleolar fraction, nucleoplasm, nucleus
