PTTG1 - pituitary tumor-transforming 1
Entrez Gene Name: pituitary tumor-transforming 1
Entrez GeneID: Human(9232)
, Mouse(30939), Rat(64193)
, Mouse(30939), Rat(64193) Synonyms: AW555095, C87862, EAP1, HPTTG, MGC126883, MGC138276, PDS1, Pituitary tumor transforming 1, PITUITARY TUMOR TRANSFORMING GENE PROTEIN1, PTTG, PTTG1, Pttg3, SECURIN, TUTR1
Gene Summary
- Human (9232): The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
cell cycle, cell division, cellular process, chromosome organization, chromosome segregation, DNA metabolic process, DNA repair, homologous chromosome segregation, mitosis, negative regulation of cell proliferation, regulation of cell growth, response to DNA damage stimulus, spermatogenesis, transcription from RNA polymerase II promoter
Literature References
- 12355087Bernal JA, Luna R, Espina A, Lazaro I, Ramos-Morales F, Romero F, Arias C, Silva A, Tortolero M, Pintor-Toro JA. Human securin interacts with p53 and modulates p53-mediated transcriptional activity and apoptosis.Nat Genet 2002 Oct;32(2):306-11
- 17975001Chesnokova V, Zonis S, Rubinek T, Yu R, Ben-Shlomo A, Kovacs K, Wawrowsky K, Melmed S. Senescence mediates pituitary hypoplasia and restrains pituitary tumor growth.Cancer Res 2007 Nov 01;67(21):10564-72
- 17039256Ying H, Furuya F, Zhao L, Araki O, West BL, Hanover JA, Willingham MC, Cheng SY. Aberrant accumulation of PTTG1 induced by a mutated thyroid hormone beta receptor inhibits mitotic progression.J Clin Invest 2006 Nov 01;116(11):2972-84 View 606 categorized literature findings and their references in IPA
Molecular Functions
cysteine-type endopeptidase inhibitor activity, heat shock protein binding, protein binding, SH3 domain binding, transcription factor activity
Protein Domains
cysteine protease inhibitor, protein binding, transcription factor, transcription regulator
Subcellular Locations
asters, chromosomes, cytoplasm, cytosol, mitotic spindle, nuclear fraction, nucleus, plasma membrane
