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IL12RB1 - interleukin 12 receptor, beta 1
Entrez Gene Name: interleukin 12 receptor, beta 1
Entrez GeneID: Human(3594)
, Mouse(16161), Rat(171333)
, Mouse(16161), Rat(171333) Synonyms: CD212, IL-12 Rβ1, IL-12R-BETA1, IL-12R b , IL12RB, IL12RB1, MGC34454
Gene Summary
- Human (3594): The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq]
- Rat (171333): transmembrane protein that belongs to the hemopoietin receptor superfamily; human homolg binds interleukin (IL)12 with a low affinity and may be a part of the IL12 receptor complex [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
cellular response to interferon-gamma, cytokine-mediated signaling pathway, interleukin-12-mediated signaling pathway, peptidyl-tyrosine phosphorylation, positive regulation of activated T cell proliferation, positive regulation of defense response to virus by host, positive regulation of interferon-gamma production, positive regulation of memory T cell differentiation, positive regulation of T cell mediated cytotoxicity, positive regulation of T-helper 1 type immune response, positive regulation of T-helper 17 cell lineage commitment, positive regulation of T-helper 17 type immune response, signal transduction
Cellular Components
external side of plasma membrane, integral to membrane, interleukin-12 receptor complex, interleukin-23 receptor complex, membrane
Literature References
- 17126601Cooper AM, Khader SA. IL-12p40: an inherently agonistic cytokine.Trends Immunol 2007 Jan 01;28(1):33-8
- 15158199Bastos KR, Marinho CR, Barboza R, Russo M, Alvarez JM, D'Império Lima MR. What kind of message does IL-12/IL-23 bring to macrophages and dendritic cells?Microbes Infect 2004 May 01;6(6):630-6
- 12948519Watford WT, Moriguchi M, Morinobu A, O'Shea JJ. The biology of IL-12: coordinating innate and adaptive immune responses.Cytokine Growth Factor Rev 2003 Oct 01;14(5):361-8
Molecular Functions
cytokine receptor activity, interleukin-12 receptor activity, interleukin-12 receptor binding, interleukin-23 binding, interleukin-23 receptor activity, receptor activity
Protein Domains
cytokine receptor, cytoplasmic domain, cytosolic tail domain, FN3, transmembrane domain, transmembrane receptor
Subcellular Locations
cell surface, cellular membrane, intracellular space, Plasma Membrane, plasma membrane extracellular face