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NR3C2 - nuclear receptor subfamily 3, group C, member 2
Entrez Gene Name: nuclear receptor subfamily 3, group C, member 2
Entrez GeneID: Human(4306)
, Mouse(110784), Rat(25672)
, Mouse(110784), Rat(25672) Synonyms: FLJ41052, MCR, MGC133092, MINERALOCORTICOID RECEPTOR, MLR, MR, NR3C2, NR3C2VIT, TYPE1 CORTICOSTEROID RECEPTOR
Gene Summary
- Human (4306): This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq]
- Rat (25672): mineralocorticoid receptor; involved in renal sodium and water regulation [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
cellular sodium ion homeostasis, excretion, gene expression, mineralocorticoid receptor signaling pathway, regulation of cell proliferation, regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor, regulation of transcription, DNA-dependent, signal transduction, steroid hormone mediated signaling pathway, transcription, DNA-dependent
Cellular Components
cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nucleoplasm, nucleus
Literature References
- 11239411Lifton RP, Gharavi AG, Geller DS. Molecular mechanisms of human hypertension.Cell 2001 Feb 23;104(4):545-56
- 21411659Yau JL, Noble J, Seckl JR. 11{beta}-Hydroxysteroid Dehydrogenase Type 1 Deficiency Prevents Memory Deficits with Aging by Switching from Glucocorticoid Receptor to Mineralocorticoid Receptor-Mediated Cognitive Control.J Neurosci 2011 Mar 16;31(11):4188-93
- 20591974Latouche C, Sainte-Marie Y, Steenman M, Castro Chaves P, Naray-Fejes-Toth A, Fejes-Toth G, Farman N, Jaisser F. Molecular signature of mineralocorticoid receptor signaling in cardiomyocytes: from cultured cells to mouse heart.Endocrinology 2010 Sep 01;151(9):4467-76
Molecular Functions
DNA binding, double-stranded DNA binding, hormone binding, metal ion binding, mineralocorticoid receptor activity, protein binding, protein heterodimerization activity, protein homodimerization activity, receptor activity, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, steroid binding, steroid hormone receptor activity, zinc ion binding
Protein Domains
AF-1 domain, AF-2 transcription activation domain, DNA binding domain, DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers, double-stranded DNA binding, hinge domain, hormone binding, hormone binding domain, ligand-binding domain, ligand-dependent nuclear receptor, mineralocorticoid receptor, nuclear receptor ligand binding domain, protein binding, protein heterodimerization, protein homodimerization, steroid binding, steroid hormone receptor, transcription factor
Subcellular Locations
cell surface, Cytoplasm, cytosolic fraction, nuclear fraction, nucleoplasm, Nucleus, soluble fraction