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HMGB1 - high mobility group box 1
Entrez Gene Name: high mobility group box 1
Entrez GeneID: Human(3146)
, Mouse(434174), Rat(680054)
, Mouse(434174), Rat(680054) Synonyms: Ac2-008, AMPHOTERIN, DEF, DKFZp686A04236, EG434174, HMG-1, Hmg1l1, HMG3, HMGB1, LOC680054, MGC103168, MGC103169, MGC117896, MGC117897, MGC93598, MGC93599, p30, SBP-1
Gene Summary
No Data Available
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
apoptosis, base-excision repair, DNA ligation, cellular component disassembly involved in apoptosis, dendritic cell chemotaxis, DNA fragmentation involved in apoptotic nuclear change, DNA ligation involved in DNA repair, DNA recombination, DNA topological change, eye development, inflammatory response to antigenic stimulus, innate immune response, lung development, myeloid dendritic cell activation, negative regulation of RNA polymerase II transcriptional preinitiation complex assembly, negative regulation of transcription from RNA polymerase II promoter, neuron projection development, positive chemotaxis, positive regulation of apoptosis, positive regulation of caspase activity, positive regulation of DNA binding, positive regulation of glycogen catabolic process, positive regulation of myeloid cell differentiation, positive regulation of transcription from RNA polymerase II promoter, regulation of transcription from RNA polymerase II promoter, response to glucocorticoid stimulus, transcription, DNA-dependent, V(D)J recombination
Cellular Components
cell surface, condensed chromosome, cytoplasm, extracellular region, extracellular space, neuron projection, nucleolus, nucleoplasm, nucleus, soluble fraction, transcriptional repressor complex
Literature References
- 20303871Zitvogel L, Kepp O, Kroemer G. Decoding cell death signals in inflammation and immunity.Cell 2010 Mar 19;140(6):798-804
- 16169070Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE. A human protein-protein interaction network: a resource for annotating the proteome.Cell 2005 Sep 23;122(6):957-68
- 12490963Cohen J. The immunopathogenesis of sepsis.Nature 2002 Dec 19;420(6917):885-91
Molecular Functions
calcium-dependent protein kinase regulator activity, chemoattractant activity, cytokine activity, damaged DNA binding, DNA bending activity, DNA binding, double-stranded DNA binding, protein binding, protein kinase activator activity, RAGE receptor binding, repressing transcription factor binding, sequence-specific DNA binding transcription factor activity, single-stranded DNA binding, transcription factor binding
Protein Domains
A domain, A-box, acidic domain, basic domain, Box B domain, chemoattractant, cytokine, damaged DNA binding, DNA bending protein, DNA binding domain, double-stranded DNA binding, HMG-box, linker domain, protein binding, RAGE-binding domain, repressing transcription factor binding, single-stranded DNA binding, transcription factor, transcription factor binding, transcription regulator
Subcellular Locations
cell surface, cellular membrane, chromosomes, Cytoplasm, cytosol, Extracellular Space, nuclear fraction, nucleoli, nucleoplasm, Nucleus, Plasma Membrane