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SGK1 - serum/glucocorticoid regulated kinase 1
Entrez Gene Name: serum/glucocorticoid regulated kinase 1
Entrez GeneID: Human(6446)
, Mouse(20393), Rat(29517)
, Mouse(20393), Rat(29517) Synonyms: Serum/Glucocorticoid Regulated Serine/Threonine Protein Kinase, SGK, SGK1
Gene Summary
- Human (6446): This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq]
- Mouse (20393): This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. This enzyme is activated by protein phosphorylation and degraded via the ubiquitination and proteasome pathway. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene was identified on chromosome 12. [provided by RefSeq]
- Rat (29517): may play a role in menory consolidation and spatial learning; may mediate aldosterone-induced signaling [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
apoptosis, cell communication, cellular response to insulin stimulus, cellular sodium ion homeostasis, glucocorticoid mediated signaling pathway, long-term memory, microtubule depolymerization, negative regulation of apoptosis, negative regulation of microtubule polymerization, neuron projection morphogenesis, peptidyl-serine phosphorylation, phosphorylation, positive regulation of cell growth, positive regulation of dendrite morphogenesis, positive regulation of sodium ion transport, protein phosphorylation, regulation of cell cycle, regulation of protein localization, response to DNA damage stimulus, response to stress, sodium ion transport, visual learning
Cellular Components
cytoplasm, endoplasmic reticulum, neuron projection, nucleus, perinuclear region of cytoplasm, plasma membrane
Literature References
- 21478911Fagerli UM, Ullrich K, Stühmer T, Holien T, Köchert K, Holt RU, Bruland O, Chatterjee M, Nogai H, Lenz G, Shaughnessy JD, Mathas S, Sundan A, Bargou RC, Dörken B, Børset M, Janz M. Serum/glucocorticoid-regulated kinase 1 (SGK1) is a prominent target gene of the transcriptional response to cytokines in multiple myeloma and supports the growth of myeloma cells.Oncogene 2011 Jul 14;30(28):3198-206
- 20624922Soundararajan R, Pearce D, Hughey RP, Kleyman TR. Role of epithelial sodium channels and their regulators in hypertension.J Biol Chem 2010 Oct 01;285(40):30363-9
- 18487207Dehner M, Hadjihannas M, Weiske J, Huber O, Behrens J. Wnt Signaling Inhibits Forkhead Box O3a-induced Transcription and Apoptosis through Up-regulation of Serum- and Glucocorticoid-inducible Kinase 1.J Biol Chem 2008 Jul 11;283(28):19201-10
Molecular Functions
3-phosphoinositide-dependent protein kinase binding, ATP binding, cofactor binding, kinase activity, nucleotide binding, phosphatidylinositol binding, protein binding, protein kinase activity, protein serine/threonine kinase activity, tau protein binding, transferase activity, transferase activity, transferring phosphorus-containing groups
Protein Domains
activation loop, alcohol group acceptor phosphotransferase, catalytic domain, cofactor binding, hydrophobic domain, kinase, kinase domain, nuclear localization sequence, PPXY motif, proline tyrosine motif, protein binding, protein kinase, Protein kinase (unclassified specificity), Protein kinase C terminal domain, Protein kinase domain, Protein Kinases, catalytic domain, protein serine/threonine kinase, Protein tyrosine kinase, Serine/Threonine protein kinases, catalytic domain, tau protein binding, Tyrosine kinase, catalytic domain
Subcellular Locations
apical membrane, Cytoplasm, cytosolic fraction, membrane fraction, neurites, Nucleus, perinuclear region, Plasma Membrane