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APOBEC3G - apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
Entrez Gene Name: apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
Entrez GeneID: Human(60489)
Synonyms: APOBEC3G, ARCD, ARP-9, bK150C2.7, CEM-15, dJ494G10.1, FLJ12740, MDS019
Gene Summary
- Human (60489): This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. The protein encoded by this gene has been found to be a specific inhibitor of human immunodeficiency virus-1 (HIV-1) infectivity. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
base conversion or substitution editing, cytidine deamination, innate immune response, interspecies interaction between organisms, negative regulation of retroviral genome replication, negative regulation of viral genome replication, negative regulation of viral reproduction, positive regulation of defense response to virus by host, response to virus, viral reproduction
Cellular Components
apolipoprotein B mRNA editing enzyme complex, cytoplasm, cytosol, mitochondrion, nucleus
Literature References
- 20592083Dang Y, Wang X, York IA, Zheng YH. Identification of a Critical T(Q/D/E)x5ADx2(I/L) Motif from Primate Lentivirus Vif Proteins That Regulate APOBEC3G and APOBEC3F Neutralizing Activity.J Virol 2010 Sep 01;84(17):8561-70
- 20219919Walker RC, Khan MA, Kao S, Goila-Gaur R, Miyagi E, Strebel K. Identification of dominant negative human immunodeficiency virus type 1 Vif mutants that interfere with the functional inactivation of APOBEC3G by virus-encoded Vif.J Virol 2010 May 01;84(10):5201-11
- 19279330Ogawa Y, Kawamura T, Kimura T, Ito M, Blauvelt A, Shimada S. Gram-positive bacteria enhance HIV-1 susceptibility in Langerhans cells, but not in dendritic cells, via Toll-like receptor activation.Blood 2009 May 21;113(21):5157-66
Molecular Functions
cytidine deaminase activity, dCTP deaminase activity, hydrolase activity, metal ion binding, protein binding, protein homodimerization activity, RNA binding, zinc ion binding
Protein Domains
active site, APOBEC-like C-terminal domain, cytidine deaminase, cytidine_deaminase-like, dCTP deaminase, enzyme, protein binding, RNA binding, zinc ion binding