CYP1A1 - cytochrome P450, family 1, subfamily A, polypeptide 1
Entrez Gene Name: cytochrome P450, family 1, subfamily A, polypeptide 1
Entrez GeneID: Human(1543)
, Mouse(13076), Rat(24296)
, Mouse(13076), Rat(24296) Synonyms: AHH, AHRR, CP11, CYP1, CYP1A1, Cyp1a2, Cyp45c, Cypc45c, CYPIA1, Cytochrome p1-450, CYTOCHROME P4501A1, Erod, P-450bnf-b, P-450MC, P1-450, P450 IA1, P450-1, P450-C, P450-P1, P4501a1, P450DX
Gene Summary
- Human (1543): This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. [provided by RefSeq]
- Rat (24296): monooxygenase that plays a role in dioxin metabolism and detoxification which is 3-methylcholanthrene-inducible [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
9-cis-retinoic acid biosynthetic process, camera-type eye development, cell proliferation, cellular amine metabolic process, coumarin metabolic process, developmental process, dibenzo-p-dioxin catabolic process, dibenzo-p-dioxin metabolic process, drug metabolic process, embryonic development ending in birth or egg hatching, flavonoid metabolic process, gut development, hepatocyte differentiation, heterocycle metabolic process, hydrogen peroxide biosynthetic process, insecticide metabolic process, liver development, maternal process involved in parturition, oxidation reduction, porphyrin metabolic process, positive regulation of S phase of mitotic cell cycle, response to antibiotic, response to arsenic, response to drug, response to food, response to herbicide, response to hyperoxia, response to hypoxia, response to iron(III) ion, response to lipopolysaccharide, response to nematode, response to organic cyclic substance, response to organic substance, response to stress, response to virus, response to vitamin A, response to wounding, toxin metabolic process, vitamin D metabolic process
Cellular Components
cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, microsome, mitochondrion
Literature References
- 17283379Korashy HM, Shayeganpour A, Brocks DR, El-Kadi AO. Induction of Cytochrome P450 1A1 by Ketoconazole and Itraconazole but not Fluconazole in Murine and Human Hepatoma Cell Lines.Toxicol Sci 2007 May 01;97(1):32-43
- 16567799Kang HJ, Kim HJ, Kim SK, Barouki R, Cho CH, Khanna KK, Rosen EM, Bae I. BRCA1 modulates xenobiotic stress-inducible gene expression by interacting with ARNT in human breast cancer cells.J Biol Chem 2006 May 26;281(21):14654-62
- 16595894Nishihashi H, Kanno Y, Tomuro K, Nakahama T, Inouye Y. Primary structure and organ-specific expression of the rat aryl hydrocarbon receptor repressor gene.Biol Pharm Bull 2006 Apr 01;29(4):640-7 View 1838 categorized literature findings and their references in IPA
Molecular Functions
aromatase activity, catalytic activity, demethylase activity, electron carrier activity, enzyme binding, flavonoid 3'-monooxygenase activity, heme binding, iron ion binding, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on diphenols and related substances as donors, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen, oxygen binding, protein binding, steroid hydroxylase activity
Subcellular Locations
cell surface, cytoplasm, endoplasmic reticulum membrane, microsomal fraction, microsome, mitochondria, mitochondrial fraction, mitochondrial membrane, nuclear fraction, nucleus, plasma membrane
