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MAML1 - mastermind-like 1 (Drosophila)
Entrez Gene Name: mastermind-like 1 (Drosophila)
Entrez GeneID: Human(9794)
, Mouse(103806), Rat(303101)
, Mouse(103806), Rat(303101) Synonyms: AI644666, AW743257, D930008C07RIK, FLJ53540, KIAA0200, MAM-1, MAML1, mKIAA0200, MM, RP23-237P10.1
Gene Summary
- Human (9794): This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
gene expression, Notch signaling pathway, positive regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-dependent, transcription, DNA-dependent
Literature References
- 16510869Shen H, McElhinny AS, Cao Y, Gao P, Liu J, Bronson R, Griffin JD, Wu L. The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis.Genes Dev 2006 Mar 15;20(6):675-88
- 12050117Fryer CJ, Lamar E, Turbachova I, Kintner C, Jones KA. Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex.Genes Dev 2002 Jun 1;16(11):1397-411
- 11101851Wu L, Aster JC, Blacklow SC, Lake R, Artavanis-Tsakonas S, Griffin JD. MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors.Nat Genet 2000 Dec 1;26(4):484-9
Molecular Functions
peptide antigen binding, protein binding, protein kinase binding, transcription coactivator activity
Protein Domains
activation domain, basic domain, MamL-1 domain, peptide antigen binding, protein binding, protein kinase binding, transcription co-activator, transcription regulator