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TAF6 - TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
Entrez Gene Name: TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
Entrez GeneID: Human(6878)
, Mouse(21343), Rat(288533)
, Mouse(21343), Rat(288533) Synonyms: AW549759, DKFZp781E21155, MGC112914, MGC:8964, p80, TAF(II)70, TAF(II)80, Taf2-70, TAF2E, TAF6, TAF70, TAFII-70, TAFII-80, TAFII85, Tata box binding protein-associated factor, tfiid subunit
Gene Summary
- Human (6878): Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1, the largest subunit of TFIID. Alternative splicing results in multiple transcript variants. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Disease:
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Biological Process
gene expression, negative regulation of cell cycle, negative regulation of cell proliferation, regulation of sequence-specific DNA binding transcription factor activity, regulation of transcription, DNA-dependent, transcription elongation from RNA polymerase II promoter, transcription from RNA polymerase II promoter, transcription initiation from RNA polymerase II promoter, transcription initiation, DNA-dependent, transcription, DNA-dependent, viral reproduction
Cellular Components
cytoplasm, MLL1 complex, nucleoplasm, nucleus, transcription factor TFIID complex, transcription factor TFTC complex
Literature References
- 15601843Shao H, Revach M, Moshonov S, Tzuman Y, Gazit K, Albeck S, Unger T, Dikstein R. Core promoter binding by histone-like TAF complexes.Mol Cell Biol 2005 Jan 01;25(1):206-19
- 12453419Nakamura T, Mori T, Tada S, Krajewski W, Rozovskaia T, Wassell R, Dubois G, Mazo A, Croce CM, Canaani E. ALL-1 Is a Histone Methyltransferase that Assembles a Supercomplex of Proteins Involved in Transcriptional Regulation.Mol Cell 2002 Nov;10(5):1119-28
- 11583621Bell B, Scheer E, Tora L. Identification of hTAF(II)80 delta links apoptotic signaling pathways to transcription factor TFIID function.Mol Cell 2001 Sep 1;8(3):591-600
Molecular Functions
DNA binding, protein binding, sequence-specific DNA binding transcription factor activity
Protein Domains
DNA binding, histone-fold domain, protein binding, TATA binding protein associated factor 6, TATA box binding protein associated factor (TAF), transcription factor, transcription regulator