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CHAF1A - chromatin assembly factor 1, subunit A (p150)

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Entrez Gene Name: chromatin assembly factor 1, subunit A (p150)
Entrez GeneID: Human(10036), Mouse(27221), Rat(363333)
Synonyms: AL023013, AL024058, Cac1p, CAF-1, CAF-1 P150, CAF1B, CHAF1A, HP150, MGC71229, P150

Gene Summary

  • Human (10036): Chromatin assembly factor I (CAF1) is a nuclear complex consisting of p50, p60 (CHAF1B; MIM 601245), and p150 (CHAF1A) subunits that assembles histone octamers onto replicating DNA in vitro (Kaufman et al., 1995 [PubMed 7600578]).[supplied by OMIM]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras

Cell Regulation

Regulates:
  • protein-protein complex
  • Histone h3
  • CHAF1A
View all 15 in IPA
Regulated by:
  • hydroxyurea
  • fulvestrant
  • RB1
View all 13 in IPA
Binds:
  • HIST1H3A (includes others)
  • PCNA
  • CBX5
View all 59 in IPA
Role in cell:
  • assembly
  • cell cycle progression
  • morphology
View all 6 in IPA
Disease:
  • colon cancer
  • infection by HIV-1
View all 4 in IPA

Biological Process

cell cycle, chromatin assembly, DNA repair, DNA replication, DNA replication-dependent nucleosome assembly, protein complex assembly, regulation of transcription, DNA-dependent, response to DNA damage stimulus, transcription, DNA-dependent

Cellular Components

CAF-1 complex, chromatin assembly complex, nucleus, WINAC complex

Literature References

  • 15306854Quivy JP, Roche D, Kirschner D, Tagami H, Nakatani Y, Almouzni G. A CAF-1 dependent pool of HP1 during heterochromatin duplication.EMBO J 2004 Sep 01;23(17):3516-26
  • 19822659Ben-Shahar TR, Castillo AG, Osborne MJ, Borden KL, Kornblatt J, Verreault A. Two Fundamentally Distinct PCNA Interaction Peptides Contribute to Chromatin Assembly Factor 1 Function.Mol Cell Biol 2009 Dec 01;29(24):6353-65
  • 17173071Jiao R, Harrigan JA, Shevelev I, Dietschy T, Selak N, Indig FE, Piotrowski J, Janscak P, Bohr VA, Stagljar I. The Werner syndrome protein is required for recruitment of chromatin assembly factor 1 following DNA damage.Oncogene 2007 May 31;26(26):3811-22
View 386 categorized literature findings and their references in IPA

Molecular Functions

chromatin binding, chromo shadow domain binding, protein binding, unfolded protein binding

Pathways

No Data Available

Protein Domains

Chromatin assembly factor 1 p150 subunit, chromatin binding, dimerization domain, ED domain, KER domain, PCNA binding domain, PEST domain, protein binding

Subcellular Locations

DNA replication foci, nuclear foci, nuclear fraction, Nucleus, pericentric heterochromatin

IPA Extras