ACTB - actin, beta
Entrez Gene Name: actin, beta
Entrez GeneID: Human(60)
, Mouse(11461), Rat(81822)
, Mouse(11461), Rat(81822) Synonyms: A-X actin, ACTB, Actin beta, Actx, BETA ACTIN, BETA CA, E430023M04Rik, Melanoma x actin, MGC128179, PS1TP5BP1
Gene Summary
- Human (60): This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, and integrity. This actin is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins. [provided by RefSeq]
- Rat (81822): mRNA expression increases following axon injury; may play a role in acceleration of axonal outgrowth [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Cellular Components
axon, cortical cytoskeleton, cytoplasm, cytoskeleton, cytosol, histone methyltransferase complex, NuA4 histone acetyltransferase complex, protein complex, soluble fraction
Literature References
- 17218253Ayala R, Shu T, Tsai LH. Trekking across the brain: the journey of neuronal migration.Cell 2007 Jan 12;128(1):29-43
- 16189514Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M. Towards a proteome-scale map of the human protein-protein interaction network.Nature 2005 Oct 20;437(7062):1173-8
- 15630019Govek EE, Newey SE, Van Aelst L. The role of the Rho GTPases in neuronal development.Genes Dev 2005 01 1;19(1):1-49
Molecular Functions
ATP binding, nitric-oxide synthase binding, nucleotide binding, protein binding, protein kinase binding, structural constituent of cytoskeleton
- ILK Signaling
- FAK Signaling
- Caveolar-mediated Endocytosis Signaling
- Tight Junction Signaling
- NRF2-mediated Oxidative Stress Response
- Leukocyte Extravasation Signaling
- VEGF Signaling
- Clathrin-mediated Endocytosis Signaling
- Integrin Signaling
- Cellular Effects of Sildenafil (Viagra)
- Agrin Interactions at Neuromuscular Junction
- Virus Entry via Endocytic Pathways
- Mechanisms of Viral Exit from Host Cells
- Regulation of Actin-based Motility by Rho
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- Germ Cell-Sertoli Cell Junction Signaling
- Actin Cytoskeleton Signaling
- Crosstalk between Dendritic Cells and Natural Killer Cells
Subcellular Locations
actin stress fibers, apical membrane, cell body, cell cortex, cell membrane leading edge, cell surface, cellular membrane, central junction, chromatin, cytoplasm, cytoplasmic foci, cytoplasmic fraction, cytoplasmic particles, cytoskeletal fraction, cytosol, cytosolic fraction, endoplasmic reticulum fraction, exosomes, filopodia, Golgi cisternae, Golgi membranes, golgi/trans-golgi network-rich vesicle fraction, growth cone, intracellular space, membrane fraction, membrane rafts, myelin enriched fraction, nerve ending, nuclear fraction, nuclear scaffolds, nucleoli, nucleus, perinuclear region, peroxisomes, phagosomes, plasma membrane, plasma membrane fraction, podosomes, postsynaptic density (PSD) fractions, pseudopodia, soluble fraction
