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ACTB - actin, beta

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Gene
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Canonical
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Literature

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Disease

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Expression

Regulation

SNP

Entrez Gene Name: actin, beta
Entrez GeneID: Human(60), Mouse(11461), Rat(81822)
Synonyms: A-X actin, ACTB, Actin beta, Actx, BETA ACTIN, BETA CA, E430023M04Rik, Melanoma x actin, MGC128179, PS1TP5BP1

Gene Summary

  • Human (60): This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, and integrity. This actin is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins. [provided by RefSeq, Jul 2008]
  • Rat (81822): mRNA expression increases following axon injury; may play a role in acceleration of axonal outgrowth [RGD, Feb 2006]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras

Cell Regulation

Regulates:
  • PLD2
  • Alpha actinin
  • Actin
View all 95 in IPA
Regulated by:
  • WAS
  • Tcr
  • F2
View all 770 in IPA
Binds:
  • GSN
  • PFN1
  • Profilin
View all 372 in IPA
Role in cell:
  • motility
  • morphology
  • formation
View all 79 in IPA
Disease:
  • amyotrophic lateral sclerosis
  • cystic fibrosis
  • acute kidney injury
View all 15 in IPA

Biological Process

'de novo' posttranslational protein folding, adherens junction organization, axon guidance, axonogenesis, blood coagulation, cell junction assembly, cell-cell junction organization, cellular component movement, cellular protein metabolic process, protein folding, response to calcium ion

Cellular Components

axon, cortical cytoskeleton, cytoplasm, cytoskeleton, cytosol, MLL5-L complex, NuA4 histone acetyltransferase complex, protein complex, ribonucleoprotein complex, soluble fraction

Literature References

  • 17218253Ayala R, Shu T, Tsai LH. Trekking across the brain: the journey of neuronal migration.Cell 2007 Jan 12;128(1):29-43
  • 16189514Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M. Towards a proteome-scale map of the human protein-protein interaction network.Nature 2005 10 20;437(7062):1173-8
  • 15630019Govek EE, Newey SE, Van Aelst L. The role of the Rho GTPases in neuronal development.Genes Dev 2005 Jan 01;19(1):1-49
View 4160 categorized literature findings and their references in IPA

Molecular Functions

ATP binding, kinesin binding, nitric-oxide synthase binding, nucleotide binding, protein binding, protein kinase binding, structural constituent of cytoskeleton, Tat protein binding

Pathways

Protein Domains

ACTIN, Actin, kinesin binding, protein binding, protein kinase binding, structural constituent of cytoskeleton

Subcellular Locations

actin stress fibers, apical membrane, axons, cell cortex, cell membrane leading edge, cell surface, cellular membrane, central junction, chromatin, cortical cytoskeleton, Cytoplasm, cytoplasmic aggregates, cytoplasmic fraction, cytoplasmic particles, cytoskeletal fraction, cytoskeleton, cytosol, cytosolic fraction, endoplasmic reticulum fraction, exosomes, filopodia, Golgi cisternae, Golgi membranes, golgi/trans-golgi network-rich vesicle fraction, growth cone, intracellular space, membrane fraction, membrane rafts, myelin enriched fraction, nerve ending, nuclear fraction, nuclear scaffolds, nucleoli, Nucleus, perikaryon, perinuclear region, peroxisomes, phagosomes, Plasma Membrane, plasma membrane fraction, podosomes, postsynaptic density (PSD) fractions, pseudopodia, soluble fraction

IPA Extras