DDT - D-dopachrome tautomerase
Entrez Gene Name: D-dopachrome tautomerase
Entrez GeneID: Human(1652)
, Mouse(13202), Rat(29318)
, Mouse(13202), Rat(29318) Synonyms: C78655, D-dopachrome tautomerase, DDCT, DDT
Gene Summary
- Human (1652): D-dopachrome tautomerase converts D-dopachrome into 5,6-dihydroxyindole. The DDT gene is related to the migration inhibitory factor (MIF) in terms of sequence, enzyme activity, and gene structure. DDT and MIF are closely linked on chromosome 22. [provided by RefSeq]
- Rat (29318): converts D-dopachrome into 5,6-dihydroxyindole [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Regulates:
| Role in cell:
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Literature References
- 17353931Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D. Large-scale mapping of human protein-protein interactions by mass spectrometry.Mol Syst Biol 2007 01 1;3:89
- 12374981Varambally S, Dhanasekaran SM, Zhou M, Barrette TR, Kumar-Sinha C, Sanda MG, Ghosh D, Pienta KJ, Sewalt RG, Otte AP, Rubin MA, Chinnaiyan AM. The polycomb group protein EZH2 is involved in progression of prostate cancer.Nature 2002 Oct 10;419(6907):624-9
- 11972069Liu K, Catalfamo M, Li Y, Henkart PA, Weng NP. IL-15 mimics T cell receptor crosslinking in the induction of cellular proliferation, gene expression, and cytotoxicity in CD8+ memory T cells.Proc Natl Acad Sci U S A 2002 Apr 30;99(9):6192-7
Molecular Functions
D-dopachrome decarboxylase activity, dopachrome isomerase activity, lyase activity, protein binding
