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SMO - smoothened, frizzled family receptor

Entrez Gene Name: smoothened, frizzled family receptor
Synonyms: bnb, E130215L21Rik, FZD11, Gx, SMO, SMOH, smoothened

Gene Summary

  • Human (6608): The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex. [provided by RefSeq]
  • Rat (25273): may act as a signaling component of the Patched (Ptch) signaling pathway [RGD]

Cell Regulation

Regulates:
  • DVL1
  • Dishevelled
  • Gαq/o
View all 52 in IPA
Regulated by:
  • Wnt
  • Patched
  • DKK
View all 27 in IPA
Binds:
  • Wnt
  • PTCH1
  • DVL1
View all 41 in IPA
Role in cell:
  • proliferation
  • apoptosis
  • growth
View all 24 in IPA
Disease:
  • cancer
  • tumorigenesis
  • skin cancer
View all 13 in IPA

Biological Process

adenohypophysis development, axon extension involved in axon guidance, canonical Wnt receptor signaling pathway, cardioblast differentiation, cell development, cell fate specification, central nervous system development, central nervous system neuron differentiation, cerebellar cortex morphogenesis, ciliary receptor clustering involved in smoothened signaling pathway, determination of left/right symmetry, developmental growth, dorsal/ventral neural tube patterning, dorsal/ventral pattern formation, embryonic camera-type eye development, embryonic digestive tract morphogenesis, embryonic neurocranium morphogenesis, embryonic viscerocranium morphogenesis, epithelial-mesenchymal cell signaling, exocrine pancreas development, facial nerve development, floor plate formation, G-protein coupled receptor protein signaling pathway, gonad development, heart morphogenesis, in utero embryonic development, multicellular organism growth, multicellular organismal development, muscle cell fate commitment, negative regulation of apoptosis, negative regulation of DNA binding, negative regulation of transcription from RNA polymerase II promoter, neural crest cell migration, neuron fate commitment, neuron projection regeneration, odontogenesis of dentine-containing tooth, osteoblast differentiation, osteoblast proliferation, otolith morphogenesis, pattern specification process, positive regulation of cell proliferation, positive regulation of epithelial cell proliferation, positive regulation of mesenchymal cell proliferation, positive regulation of neuroblast proliferation, positive regulation of protein import into nucleus, positive regulation of smoothened signaling pathway, positive regulation of transcription from RNA polymerase II promoter, protein localization to nucleus, protein stabilization, regulation of gene expression, response to organic substance, response to wounding, semicircular canal morphogenesis, signal transduction, smoothened signaling pathway, smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation, smoothened signaling pathway involved in ventral spinal cord patterning, spermatogenesis, vasculogenesis

Cellular Components

cilium, cytoplasm, integral to membrane, membrane, neuronal cell body, plasma membrane

Literature References

  • 15107405Jeong J, Mao J, Tenzen T, Kottmann AH, McMahon AP. Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia.Genes Dev 2004 Apr 15;18(8):937-51
  • 18756266Ferretti E, De Smaele E, Miele E, Laneve P, Po A, Pelloni M, Paganelli A, Di Marcotullio L, Caffarelli E, Screpanti I, Bozzoni I, Gulino A. Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells.EMBO J 2008 10 8;27(19):2616-27
  • 10981962Outram SV, Varas A, Pepicelli CV, Crompton T. Hedgehog signaling regulates differentiation from double-negative to double-positive thymocyte.Immunity 2000 Aug 1;13(2):187-97
View 492 categorized literature findings and their references in IPA

Molecular Functions

binding, G-protein coupled receptor activity, PDZ domain binding, protein binding, receptor activity, signal transducer activity, Wnt receptor activity, Wnt-protein binding

Protein Domains

binding protein, CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain, Frizzled/Smoothened family membrane region, G-protein coupled receptor, PDZ-domain binding, protein binding, receptor, Wnt receptor, Wnt-protein binding

Subcellular Locations

cell surface, cellular membrane, cilia, Cytoplasm, perikaryon, Plasma Membrane, vesicles