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AQP1 - aquaporin 1 (Colton blood group)
Canonical
Pathway
Entrez Gene Name: aquaporin 1 (Colton blood group)
Entrez GeneID: Human(358)
, Mouse(11826), Rat(25240)
, Mouse(11826), Rat(25240) Synonyms: Aq1, AQP-CHIP, AQP1, AQUAPORIN 1, Aquaporin-CHIP, Channel integral membrane protein 28, CHIP28, CO, MGC26324
Gene Summary
- Human (358): Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). This gene encodes an aquaporin which functions as a molecular water channel protein. It is a homotetramer with 6 bilayer spanning domains and N-glycosylation sites. The protein physically resembles channel proteins and is abundant in erythrocytes and renal tubes. The gene encoding this aquaporin is a possible candidate for disorders involving imbalance in ocular fluid movement. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
- Rat (25240): integral membrane protein that is a major water transport molecule in the kidney proximal tubule and red blood cells [RGD, Feb 2006]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
ammonium transport, camera-type eye morphogenesis, carbon dioxide transmembrane transport, carbon dioxide transport, cell volume homeostasis, cellular homeostasis, cellular hyperosmotic response, cellular response to cAMP, cellular response to copper ion, cellular response to dexamethasone stimulus, cellular response to hydrogen peroxide, cellular response to hypoxia, cellular response to inorganic substance, cellular response to mechanical stimulus, cellular response to mercury ion, cellular response to nitric oxide, cellular response to retinoic acid, cellular response to salt stress, cellular response to stress, cellular response to UV, cerebrospinal fluid secretion, cGMP biosynthetic process, corticotropin secretion, establishment or maintenance of actin cytoskeleton polarity, glomerular filtration, glycerol transport, hyperosmotic response, hyperosmotic salinity response, lateral ventricle development, lipid digestion, maintenance of symbiont-containing vacuole via substance secreted by host, metanephric descending thin limb development, metanephric glomerulus vasculature development, metanephric proximal convoluted tubule segment 2 development, metanephric proximal straight tubule development, multicellular organismal water homeostasis, negative regulation of apoptosis, nitric oxide transport, odontogenesis, pancreatic juice secretion, positive regulation of angiogenesis, positive regulation of cell migration, positive regulation of epithelial cell migration, positive regulation of fibroblast proliferation, positive regulation of lamellipodium assembly, positive regulation of saliva secretion, potassium ion transmembrane transport, potassium ion transport, renal water absorption, renal water transport, response to drug, response to estrogen stimulus, response to hormone stimulus, secretion by cell, secretory granule organization, sensory perception of pain, transepithelial water transport, transmembrane transport, transport, water homeostasis, water transport, wound healing
Cellular Components
apical part of cell, apical plasma membrane, axon part, axon terminus, basal plasma membrane, basolateral plasma membrane, brush border, brush border membrane, cytoplasm, dense core granule membrane, extracellular vesicular exosome, integral to membrane, integral to membrane of membrane fraction, integral to plasma membrane, membrane, membrane fraction, microvillus, neuron projection, neuronal cell body membrane, nuclear membrane, nucleus, plasma membrane, sarcolemma, symbiont-containing vacuole, symbiont-containing vacuole membrane
Literature References
- 16189514Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M. Towards a proteome-scale map of the human protein-protein interaction network.Nature 2005 10 20;437(7062):1173-8
- 20639513Lanaspa MA, Andres-Hernando A, Li N, Rivard CJ, Cicerchi C, Roncal-Jimenez C, Schrier RW, Berl T. The expression of aquaporin-1 in the medulla of the kidney is dependent on the transcription factor associated with hypertonicity, TonEBP.J Biol Chem 2010 Oct 08;285(41):31694-703
- 20628061Sepramaniam S, Armugam A, Lim KY, Karolina DS, Swaminathan P, Tan JR, Jeyaseelan K. MicroRNA 320a Functions as a Novel Endogenous Modulator of Aquaporins 1 and 4 as Well as a Potential Therapeutic Target in Cerebral Ischemia.J Biol Chem 2010 Sep 17;285(38):29223-30
Molecular Functions
ammonia transmembrane transporter activity, carbon dioxide transmembrane transporter activity, ephrin receptor binding, glycerol transmembrane transporter activity, intracellular cGMP activated cation channel activity, nitric oxide transmembrane transporter activity, potassium channel activity, potassium ion transmembrane transporter activity, protein binding, transmembrane transporter activity, transporter activity, water channel activity, water transmembrane transporter activity
Protein Domains
glycerol transporter, intracellular cGMP activated cation channel, MIP, nitric oxide transporter, potassium channel, potassium ion transporter, protein binding, transmembrane domain, transporter, water channel, water transporter
Subcellular Locations
apical compartment, apical membrane, axon component, axon terminals, basal membrane, basolateral cell surfaces, basolateral membrane, brush border, caveolae, cellular membrane, Cytoplasm, cytoplasmic vesicles, exosomes, inner membrane, membrane fraction, microvilli, neurites, nuclear envelope, Nucleus, perikaryon, Plasma Membrane, sarcolemma, secretory vesicles, vesicles