-
Product Directory
Custom Product
-
Services Offered
Custom Capabilities
-
UIMC1 - ubiquitin interaction motif containing 1
Canonical
Pathway
Entrez Gene Name: ubiquitin interaction motif containing 1
Entrez GeneID: Human(51720)
, Mouse(20184), Rat(290997)
, Mouse(20184), Rat(290997) Synonyms: 9430016E08Rik, D330018D10Rik, D630032M02Rik, RAP80, RETINOID X RECEPTOR INTERACTING, RGD1307009, RIP110, RXRIP110, UIMC1, X2HRIP110
Gene Summary
No Data Available
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
chromatin modification, DNA repair, double-strand break repair, G2/M transition DNA damage checkpoint, histone H2A K63-linked deubiquitination, negative regulation of transcription, DNA-dependent, positive regulation of DNA repair, regulation of transcription, DNA-dependent, response to DNA damage stimulus, response to ionizing radiation, transcription, DNA-dependent
Literature References
- 19615732Sowa ME, Bennett EJ, Gygi SP, Harper JW. Defining the human deubiquitinating enzyme interaction landscape.Cell 2009 07 23;138(2):389-403
- 17525340Wang B, Matsuoka S, Ballif BA, Zhang D, Smogorzewska A, Gygi SP, Elledge SJ. Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response.Science 2007 05 25;316(5828):1194-8
- 19433585Yan J, Menendez D, Yang XP, Resnick MA, Jetten AM. A Regulatory Loop Composed of RAP80-HDM2-p53 Provides RAP80-enhanced p53 Degradation by HDM2 in Response to DNA Damage.J Biol Chem 2009 Jul 17;284(29):19280-9
Molecular Functions
histone binding, K63-linked polyubiquitin binding, protein binding, retinoid X receptor binding
Protein Domains
histone binding, protein binding, retinoid X receptor binding, ubiquitin binding domain, zinc finger domain