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MYC - v-myc myelocytomatosis viral oncogene homolog (avian)
Entrez Gene Name: v-myc myelocytomatosis viral oncogene homolog (avian)
Entrez GeneID: Human(4609)
, Mouse(17869), Rat(24577)
, Mouse(17869), Rat(24577) Synonyms: AU016757, bHLHe39, C-MYC, C-MYC-P64, MGC105490, MGC138120, mMyc, MRTL, MYC, Myc2, Niard, Nird, RNCMYC
Gene Summary
- Human (4609): The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq]
- Mouse (17869): The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma, in human. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini, in human and mouse. Under conditions of stress, such as high cell densities and methionine deprivation, there is a specific and dramatic increase in the synthesis of the non-AUG initiated protein, suggesting its importance in times of adversity. Alternative splicing results in multiple transcript variants. [provided by RefSeq]
- Rat (24577): The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma, in human. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini, in human and mouse. Rat mRNA also has a similarly placed CUG upstream of the AUG start site, suggesting that it may also produce two Myc proteins. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
activation of caspase activity, activation of pro-apoptotic gene products, B cell apoptosis, branching involved in ureteric bud morphogenesis, cell cycle arrest, cell proliferation, cellular iron ion homeostasis, cellular response to protein stimulus, detection of mechanical stimulus involved in sensory perception of sound, DNA fragmentation involved in apoptotic nuclear change, glucose metabolic process, induction of apoptosis by intracellular signals, middle ear morphogenesis, negative regulation of protein binding, negative regulation of survival gene product expression, negative regulation of transcription from RNA polymerase II promoter, pathogenesis, pigmentation, positive regulation of B cell apoptosis, positive regulation of catalytic activity, positive regulation of cell proliferation, positive regulation of mesenchymal cell proliferation, positive regulation of metanephric cap mesenchymal cell proliferation, positive regulation of transcription from RNA polymerase II promoter, positive regulation of transcription, DNA-dependent, protein processing, regulation of apoptosis, regulation of gene expression, regulation of mitotic cell cycle, regulation of telomere maintenance, regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-dependent, release of cytochrome c from mitochondria, response to alkaloid, response to drug, response to radiation, skeletal system morphogenesis, transcription from RNA polymerase II promoter, transcription initiation, DNA-dependent, transcription, DNA-dependent, Wnt receptor signaling pathway
Literature References
- 17646409O'neil J, Grim J, Strack P, Rao S, Tibbitts D, Winter C, Hardwick J, Welcker M, Meijerink JP, Pieters R, Draetta G, Sears R, Clurman BE, Look AT. FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to {gamma}-secretase inhibitors.J Exp Med 2007 Aug 06;204(8):1813-24
- 16847353Weng AP, Millholland JM, Yashiro-Ohtani Y, Arcangeli ML, Lau A, Wai C, Del Bianco C, Rodriguez CG, Sai H, Tobias J, Li Y, Wolfe MS, Shachaf C, Felsher D, Blacklow SC, Pear WS, Aster JC. c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma.Genes Dev 2006 Aug 01;20(15):2096-109
- 15455033Beer S, Zetterberg A, Ihrie RA, McTaggart RA, Yang Q, Bradon N, Arvanitis C, Attardi LD, Feng S, Ruebner B, Cardiff RD, Felsher DW. Developmental context determines latency of MYC-induced tumorigenesis.PLoS Biol 2004 Nov 01;2(11):e332
Molecular Functions
DNA binding, double-stranded DNA binding, E-box binding, protein binding, protein heterodimerization activity, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity
- Chronic Myeloid Leukemia Signaling
- Small Cell Lung Cancer Signaling
- Thyroid Cancer Signaling
- P2Y Purigenic Receptor Signaling Pathway
- Thrombopoietin Signaling
- Glioblastoma Multiforme Signaling
- Wnt/β-catenin Signaling
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Myc Mediated Apoptosis Signaling
- Endothelin-1 Signaling
- PDGF Signaling
- Acute Myeloid Leukemia Signaling
- Polyamine Regulation in Colon Cancer
- Molecular Mechanisms of Cancer
- Neuregulin Signaling
- ERK/MAPK Signaling
- Aryl Hydrocarbon Receptor Signaling
- ILK Signaling
- p38 MAPK Signaling
- Prolactin Signaling
- Colorectal Cancer Metastasis Signaling
- ERK5 Signaling
- Bladder Cancer Signaling
- Cell Cycle: G1/S Checkpoint Regulation
- Endometrial Cancer Signaling
Protein Domains
Acidic casein kinase ii consensus phosphorylation site, acidic domain, activation domain, antigenic epitope, basic domain, basic helix-loop-helix-leucine zipper domain, Box I domain, Box II domain, conserved domain, dimerization domain, DNA binding, DNA binding domain, double-stranded DNA binding, helical domain, helix-loop-helix domain, HLH, leucine zipper domain, Myc amino-terminal region, Myc box I, Myc box II, Myc leucine zipper domain, NDB domain, nuclear localization sequence, Pak2 phosphorylation site, PEST domain, phosphorylation site, protein binding, protein heterodimerization, regulatory domain, transcription activation domain, transcription factor, transcription regulator, transcription repression domain
Subcellular Locations
axons, Cytoplasm, cytosol, detergent-insoluble fractions, detergent-soluble fraction, microtubules, mitochondria, mitotic spindle, nuclear bodies, nuclear fraction, nuclear matrix, nucleoli, nucleoplasm, Nucleus