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XRN1 - 5'-3' exoribonuclease 1

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Gene
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Interaction
Network

Canonical
Pathway

Literature

Clinical Trial

Disease

Compound

Expression

Regulation

SNP

Entrez Gene Name: 5'-3' exoribonuclease 1
Entrez GeneID: Human(54464), Mouse(24127), Rat(300944)
Synonyms: 5'-3' exonuclease, C78334, Dhm2, DKFZp434P0721, DKFZp686B22225, DKFZp686F19113, exo, FLJ41903, mXrn1, RGD1309713, SEP1, XRN1

Gene Summary

  • Human (54464): SEP1 localizes to cytoplasmic foci containing a complex of mRNA-degrading enzymes. In addition to mRNA metabolism, yeast Sep1 has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly.[supplied by OMIM]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras

Cell Regulation

Regulates:
  • CSF2
View all 1 in IPA
Regulated by:
  • INSR
  • IGF2
  • Ins
View all 5 in IPA
Binds:
  • UPF1
  • UPF2
  • DCP1A
View all 130 in IPA
Role in cell:
  • No Data Available
Disease:
  • No Data Available

Biological Process

cell aging, exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay, histone mRNA catabolic process, meiosis, mRNA metabolic process, nuclear mRNA surveillance, nuclear-transcribed mRNA catabolic process, nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, RNA metabolic process, RNA processing, rRNA catabolic process, telomere maintenance

Cellular Components

cytoplasm, cytosol, Golgi apparatus, intermediate filament cytoskeleton, intracellular, plasma membrane

Literature References

  • 15231747Lehner B, Sanderson CM. A protein interaction framework for human mRNA degradation.Genome Res 2004 Jul 01;14(7):1315-23
  • 17369404Franks TM, Lykke-Andersen J. TTP and BRF proteins nucleate processing body formation to silence mRNAs with AU-rich elements.Genes Dev 2007 Mar 15;21(6):719-35
  • 20711500Dyer MD, Neff C, Dufford M, Rivera CG, Shattuck D, Bassaganya-Riera J, Murali TM, Sobral BW. The Human-Bacterial Pathogen Protein Interaction Networks of Bacillus anthracis, Francisella tularensis, and Yersinia pestis.PLoS One 2010 Aug 09;5(8):e12089
View 231 categorized literature findings and their references in IPA

Molecular Functions

5'-3' exonuclease activity, 5'-3' exoribonuclease activity, DNA binding, exonuclease activity, hydrolase activity, nuclease activity, nucleic acid binding, protein binding, RNA binding

Pathways

No Data Available

Protein Domains

5'-3' exoribonuclease, enzyme, protein binding, XRN 5'-3' exonuclease N-terminus

Subcellular Locations

Cytoplasm, cytoplasmic aggregates, cytosol, Golgi apparatus, intermediate filament cytoskeleton, Plasma Membrane

IPA Extras