A9528

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A9528

Sigma

 

Amphotericin B solubilized

powder, γ-irradiated, cell culture tested

Synonym:Amphotericin B from Streptomyces sp., Fungizone
CAS Number:1397-89-3
Linear Formula:C47H73NO17
Molecular Weight:924.08
Beilstein Registry Number:78342
MDL number:MFCD00877763
PubChem Substance ID:24891468

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Description

Frequently Asked QuestionsLive Chat and Frequently Asked Questions are available for this Product.
ApplicationRecommended for use in cell culture applications at 5.6 mg (solid)/L.
Biochem/physiol ActionsPolyene antifungal antibiotic from Streptomyces. Affinity for sterols, primarily ergosterols, of fungal cell membranes. Forms channels in the membranes, causing small molecules to leak out.
Antimicrobial spectrum: fungi and yeast.
 Mode of Action: Interferes with fungal membrane permeability by forming channels in the membranes and causing small molecules to leak out.
PackagingPackage size based on amphotericin B

Properties

sterilityγ-irradiated
formpowder
solubilitysterile water: 20 mg/mL (as a stock solution. Stock solutions should be stored at −20 °C. Stable at 37 °C for 3 days.)
suitabilitycell culture tested
storage temp.2-8°C

Safety

Personal Protective Equipmentdust mask type N95 (US), Eyeshields, Gloves
Hazard CodesXn
Risk Statements22-36/37/38
Safety Statements26
WGK Germany3

References

referencePerlman, D., Use of antibiotics in cell culture media. Meth. Enzymol. LVIII, 112, (1979)
MerckMerck 13,590
BeilsteinBeil. 18,V,10,525

Components

  Standard component
Description
Amphotericin B ~45%
Sodium deoxycholate ~35%
Sodium phosphate balance