G1264

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G1264

Sigma

 

Gentamicin sulfate salt

powder, cell culture tested

CAS Number:1405-41-0
EC Number:215-778-9
MDL number:MFCD00270181

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Description

ApplicationRecommended for use in cell culture applications at 50 mg/L
Biochem/physiol ActionsMode of action: Gentamicin causes codon misreading by binding to the 30S ribosomal subunit, blocking the translocation of peptidyl-tRNA from the acceptor site to the donor site.1,2 The bactericidal effect of gentamicin on Pseudomonas aeruginosa is exerted by the binding of gentamicin to the outer membrane, where it displaces natural cations, destabilizes the membrane, and forms holes in the cell surface.3
Antimicrobial spectrum: Gram-negative bacteria, Staphylococcus aureus and other Gram-positive bacteria

Properties

formpowder
potency~600 μg Gentamicin per mg
solubilityH2O: 50 mg/mL (As stock solution, store at −20°C. Stable at 37°C for 5 days.)
suitabilitycell culture tested
storage temp.2-8°C

Safety

Personal Protective Equipmentdust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard CodesXn
Risk Statements42/43
Safety Statements22-36/37-45
WGK Germany2
RTECSLY2625000

References

Cited Reference1. Korzybski, T., et al. Antibiotics: origin, nature, and properties Washington, DC , (1977), 712-723
 2. Lorian, V. (ed.) Antibiotics in Laboratory Medicine 2nd ed., Baltimore, MD , (1986), 694-696
 3. Kadurugamuwa, J., et al., Surface action of gentamicin on Pseudomonas aeruginosa J. Bacteriol. 175, 5798-5805, (1993)