P4932
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P4932
Sigma
Polymyxin B sulfate salt
powder, cell culture tested
| CAS Number: | 1405-20-5 |
| Linear Formula: | C55H96N16O13 · 2H2SO4 |
| Molecular Weight: | 1385.61 |
| EC Number: | 215-774-7 |
| MDL number: | MFCD00131991 |
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Description
| Application | Recommended for use in cell culture applications at 50 mg/L. |
| Biochem/physiol Actions | Antibiotic with bactericidal action on E. coli.1,2 Binds to the lipid A portion of bacterial lipopolysaccharides.3 Induces pore formation in the membranes of cortex cells from excised sorghum roots.4 Mode of Action: Binds to and interferes with the permeability of the cytoplasmic membrane. Antimicrobial spectrum: Gram-negative bacteria. |
| Other Notes | Mixture of Polymyxin B1 and B2 sulfate. |
| Stock solutions should be sterile filtered and stored at 2-8 °C. Stable at 37 °C for 5 days. |
Properties
| form | powder |
| potency | ≥6,000 USP units per mg |
| solubility | H2O: 50 mg/mL |
| suitability | cell culture tested |
| storage temp. | 2-8°C |
Safety
| Personal Protective Equipment | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| RTECS | TR1150000 |
References
| Cited Reference | 1. Cornu, J. Ann. Microbiol. 131B, 121, (1980) |
| 2. Storm, D.R., et al. Annu. Rev. Biochem. 46, 723, (1977) | |
| 3. Morrison, D.C. and Jacobs, D.M. Immunochemistry 13, 813, (1976) | |
| 4. Lerner, H.R., et al. Physiol. Plant. 57, 90, (1983) | |
| Merck | Merck 13,7656 |
