S1323
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S1323
Sigma
SID7969543
≥98% (HPLC), solid
| Synonym: | 2-[2-[(2,3-Dihydrobenzo[1,4]dioxin-6-ylcarbamoyl)methyl]-1-oxo-1,2-dihydroisoquinolin-5-yloxy]propionic acid ethyl ester |
| CAS Number: | 868224-64-0 |
| Linear Formula: | C24H24N2O7 |
| Molecular Weight: | 452.46 |
| MDL number: | MFCD04473853 |
Description
| Biochem/physiol Actions | SID7969543 is a SF-1 (or NR5A1) inhibitor. The Steroidogenic Factor 1 (SF-1, also known as NR5A1) is a transcription factor belonging to the nuclear receptor superfamily. It plays a central role in sex determination and the formation of steroidogenic tissues during development, and is involved in endocrine function throughout life. It has also been reported to have a potential role in obesity. It has also been observed that an increased concentration of SF-1 causes adrenocortical cell proliferation and cancer. |
Properties
| assay | ≥98% (HPLC) |
| form | solid |
| color | white to off-white |
| solubility | DMSO: 10 mg/mL |
| storage temp. | 2-8°C |
Safety
| Personal Protective Equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
References
| reference | Madoux, F, et al., Potent, selective and cell penetrant inhibitors of SF-1 by functional uHTS. Mol. Pharmacol. 73, 1776-1784, (2008) |
