C1997
Sigma
CYM-5442
≥98% (HPLC)
| Synonym: | 2-(4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino) ethanol |
| CAS Number: | 1094042-01-9 |
| Linear Formula: | C23H27N3O4 |
| Molecular Weight: | 409.48 |
| MDL number: | MFCD12912402 |
Description
| Biochem/physiol Actions | CYM-5442 is a highly-selective S1P1 (Spingosine 1-Phosphate Receptor 1) agonist that activates S1P1-dependent pathways in vitro and to levels of full efficacy in vivo through a hydrophobic pocket, separable from the orthosteric site of S1P binding that is headgroup dependent. This is a different site from those involved in the activities of other agonists such as FTY720 and SEW2871. |
Properties
| assay | ≥98% (HPLC) |
| solubility | DMSO: 5 mg/mL |
| storage temp. | −20°C |
Safety
| Personal Protective Equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
References
| reference | Gonzalez-Cabrera P.J., et al., Full pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like head-group interactions. Mol. Pharmacol., (2008) |
