MTNR1A - melatonin receptor 1A
Entrez Gene Name: melatonin receptor 1A
Entrez GeneID: Human(4543)
, Mouse(17773), Rat(114211)
, Mouse(17773), Rat(114211) Synonyms: MEL-1A-R, Melatonin Receptor, MelR, MGC151277, MR, MT1, MTNR1A
Gene Summary
- Human (4543): This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. [provided by RefSeq]
- Rat (114211): G-protein coupled receptor for melatonin; involved in circardian rhythm and reproductive function [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Role in cell:
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Biological Process
circadian rhythm, G-protein coupled receptor protein signaling pathway, G-protein signaling, coupled to cyclic nucleotide second messenger, mating behavior, signal transduction
Literature References
- 17215244Daulat AM, Maurice P, Froment C, Guillaume JL, Broussard C, Monsarrat B, Delagrange P, Jockers R. Purification and identification of G protein-coupled receptor protein complexes under native conditions.Mol Cell Proteomics 2007 05 1;6(5):835-44
- 15266022Ayoub MA, Levoye A, Delagrange P, Jockers R. Preferential Formation of MT1/MT2 Melatonin Receptor Heterodimers with Distinct Ligand Interaction Properties Compared with MT2 Homodimers.Mol Pharmacol 2004 Aug 01;66(2):312-21
- 10698201Gubitz AK, Reppert SM. Chimeric and point-mutated receptors reveal that a single glycine residue in transmembrane domain 6 is critical for high affinity melatonin binding.Endocrinology 2000 Mar;141(3):1236-44 View 179 categorized literature findings and their references in IPA
Molecular Functions
G-protein coupled receptor activity, melatonin receptor activity, receptor activity, signal transducer activity
Protein Domains
carboxy terminal domain, G-protein coupled receptor, melatonin receptor, neuropeptide Y receptor
