CERK - ceramide kinase
Entrez Gene Name: ceramide kinase
Entrez GeneID: Human(64781)
, Mouse(223753), Rat(300129)
, Mouse(223753), Rat(300129) Synonyms: AI848610, CERK, D330016D08Rik, dA59H18.2, dA59H18.3, DKFZp434E0211, FLJ21430, FLJ23239, hCERK, KIAA1646, LK4, MGC131878, mKIAA1646
Gene Summary
- Human (64781): CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated in various cellular processes, including proliferation, apoptosis, phagocytosis, and inflammation (Kim et al., 2006 [PubMed 16488390]).[supplied by OMIM]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Binds:
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Biological Process
activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway, ceramide metabolic process
Cellular Components
cytoplasm, integral to membrane of membrane fraction, membrane, membrane fraction
Literature References
- 15585321Baumruker T, Bornancin F, Billich A. The role of sphingosine and ceramide kinases in inflammatory responses.Immunol Lett 2005 Jan 31;96(2):175-85
- 17554300Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.Nature 2007 06 7;447(7145):661-78
- 12855693Pettus BJ, Bielawska A, Spiegel S, Roddy P, Hannun YA, Chalfant CE. Ceramide kinase mediates cytokine and calcium ionophore-induced arachidonic acid release.J Biol Chem 2003 10 3;278(40):38206-13 View 57 categorized literature findings and their references in IPA
Molecular Functions
ATP binding, calcium ion binding, ceramide kinase activity, diacylglycerol kinase activity, kinase activity, magnesium ion binding, nucleotide binding, transferase activity
Subcellular Locations
cellular membrane, cytoplasm, cytosol, Golgi apparatus, membrane fraction, plasma membrane
