HLA-DQB1 - major histocompatibility complex, class II, DQ beta 1
Entrez Gene Name: major histocompatibility complex, class II, DQ beta 1
Entrez GeneID: Human(3119)
Synonyms: CELIAC1, HLA DR3,3, HLA-DQB, HLA-DQB1, IDDM1
Gene Summary
- Human (3119): HLA-DQB1 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Disease:
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Biological Process
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II, immune response
Literature References
- 18046453Rocha N, Neefjes J. MHC class II molecules on the move for successful antigen presentation.EMBO J 2008 Jan 09;27(1):1-5
- 16055747Rezaie P, Pontikis CC, Hudson L, Cairns NJ, Lantos PL. Expression of cellular prion protein in the frontal and occipital lobe in Alzheimer's disease, diffuse Lewy body disease, and in normal brain: an immunohistochemical study.J Histochem Cytochem 2005 Aug 01;53(8):929-40
- 14586411Croce M, De Ambrosis A, Corrias MV, Pistoia V, Occhino M, Meazza R, Giron-Michel J, Azzarone B, Accolla RS, Ferrini S. Different levels of control prevent interferon-gamma-inducible HLA-class II expression in human neuroblastoma cells.Oncogene 2003 Oct 30;22(49):7848-57 View 968 categorized literature findings and their references in IPA
