NGF - nerve growth factor (beta polypeptide)
Entrez Gene Name: nerve growth factor (beta polypeptide)
Entrez GeneID: Human(4803)
, Mouse(18049), Rat(310738)
, Mouse(18049), Rat(310738) Synonyms: Beta-NGF, HSAN5, MGC161426, MGC161428, NGF, Ngf beta, NGFB
Gene Summary
- Human (4803): This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
adult locomotory behavior, inflammatory response, memory, negative regulation of neuron apoptosis, nerve growth factor processing, neuron projection development, peripheral nervous system development, positive regulation of axon extension, positive regulation of cell growth, positive regulation of cell proliferation, Ras protein signal transduction, regulation of neuron differentiation, regulation of neurotransmitter secretion, response to drug, response to electrical stimulus, response to glucocorticoid stimulus, response to lipopolysaccharide, response to mechanical stimulus, response to organic cyclic substance, response to organic substance, response to peptide hormone stimulus, response to radiation, sensory perception of pain, transmembrane receptor protein tyrosine kinase signaling pathway
Cellular Components
endoplasmic reticulum lumen, endosome, extracellular region, extracellular space, Golgi lumen
Literature References
- 15630019Govek EE, Newey SE, Van Aelst L. The role of the Rho GTPases in neuronal development.Genes Dev 2005 01 1;19(1):1-49
- 14985763Nykjaer A, Lee R, Teng KK, Jansen P, Madsen P, Nielsen MS, Jacobsen C, Kliemannel M, Schwarz E, Willnow TE, Hempstead BL, Petersen CM. Sortilin is essential for proNGF-induced neuronal cell death.Nature 2004 Feb 26;427(6977):843-8
- 12818176Putcha GV, Le S, Frank S, Besirli CG, Clark K, Chu B, Alix S, Youle RJ, LaMarche A, Maroney AC, Johnson EM. JNK-Mediated BIM Phosphorylation Potentiates BAX-Dependent Apoptosis.Neuron 2003 Jun 19;38(6):899-914 View 5095 categorized literature findings and their references in IPA
Molecular Functions
growth factor activity, nerve growth factor receptor binding, receptor binding, receptor signaling protein activity
Protein Domains
carboxy terminal domain, growth factor, loop domain, nerve growth factor receptor binding, receptor signaling protein
Subcellular Locations
cell surface, cytoplasm, extracellular space, granules, plasma membrane, vesicles
