MAPK3 - mitogen-activated protein kinase 3
Entrez Gene Name: mitogen-activated protein kinase 3
Entrez GeneID: Human(5595)
, Mouse(26417), Rat(50689)
, Mouse(26417), Rat(50689) Synonyms: ERK-1, Esrk1, HS44KDAP, HUMKER1A, Mapk p44, MAPK3, Mapkapk3, MGC20180, P44, p44-erk, P44ERK1, P44MAPK, PRKM3
Gene Summary
- Human (5595): The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. [provided by RefSeq]
- Rat (50689): kinase involved in intracellular signalling; component of Mapk signalling pathway [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
cartilage development, cell cycle, interspecies interaction between organisms, intracellular signaling cascade, lipopolysaccharide-mediated signaling pathway, MAPKKK cascade, nuclear translocation of MAPK, organ morphogenesis, phosphorylation, positive regulation of transcription, positive regulation of translation, protein amino acid phosphorylation, protein kinase cascade, Ras protein signal transduction, regulation of transcription factor activity, response to DNA damage stimulus, response to exogenous dsRNA, response to lipopolysaccharide, sensory perception of pain, signal transduction
Cellular Components
cytoplasm, cytoskeleton, cytosol, insoluble fraction, nucleolus, nucleoplasm, nucleus, protein complex, soluble fraction
Literature References
- 15616583Chen CH, Wang WJ, Kuo JC, Tsai HC, Lin JR, Chang ZF, Chen RH. Bidirectional signals transduced by DAPK-ERK interaction promote the apoptotic effect of DAPK.EMBO J 2005 Jan 26;24(2):294-304
- 12598680Segal RA. Selectivity in neurotrophin signaling: theme and variations.Annu Rev Neurosci 2003 Jan 01;26:299-330
- 11807174Juliano RL. Signal transduction by cell adhesion receptors and the cytoskeleton: functions of integrins, cadherins, selectins, and immunoglobulin-superfamily members.Annu Rev Pharmacol Toxicol 2002;42:283-323 View 17490 categorized literature findings and their references in IPA
Molecular Functions
ATP binding, kinase activity, MAP kinase activity, nucleotide binding, phosphotyrosine binding, protein binding, protein kinase activity, protein serine/threonine kinase activity, transcription factor activity, transferase activity
- CREB Signaling in Neurons
- NF-κB Activation by Viruses
- IL-12 Signaling and Production in Macrophages
- BMP signaling pathway
- FAK Signaling
- IGF-1 Signaling
- cAMP-mediated Signaling
- CCR3 Signaling in Eosinophils
- Aldosterone Signaling in Epithelial Cells
- mTOR Signaling
- Cholecystokinin/Gastrin-mediated Signaling
- Aryl Hydrocarbon Receptor Signaling
- Actin Cytoskeleton Signaling
- Antiproliferative Role of Somatostatin Receptor 2
- Pancreatic Adenocarcinoma Signaling
- Androgen Signaling
- Gα12/13 Signaling
- Renal Cell Carcinoma Signaling
- Acute Phase Response Signaling
- PDGF Signaling
- LPS-stimulated MAPK Signaling
- ERK/MAPK Signaling
- Fc Epsilon RI Signaling
- CD40 Signaling
- Neurotrophin/TRK Signaling
- EGF Signaling
- CNTF Signaling
- HIF1α Signaling
- IL-22 Signaling
- Erythropoietin Signaling
- Ephrin Receptor Signaling
- Nicotinate and Nicotinamide Metabolism
- Inositol Phosphate Metabolism
- GM-CSF Signaling
- Lymphotoxin β Receptor Signaling
- Relaxin Signaling
- 14-3-3-mediated Signaling
- Growth Hormone Signaling
- MIF Regulation of Innate Immunity
- Cardiac Hypertrophy Signaling
- Renin-Angiotensin Signaling
- GNRH Signaling
- Corticotropin Releasing Hormone Signaling
- Estrogen Receptor Signaling
- Xenobiotic Metabolism Signaling
- G Beta Gamma Signaling
- p70S6K Signaling
- G-Protein Coupled Receptor Signaling
- Melatonin Signaling
- Prolactin Signaling
- Thrombopoietin Signaling
- PPARα/RXRα Activation
- Bladder Cancer Signaling
- Systemic Lupus Erythematosus Signaling
- 4-1BB Signaling in T Lymphocytes
- fMLP Signaling in Neutrophils
- Prostate Cancer Signaling
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- Endothelin-1 Signaling
- Synaptic Long Term Potentiation
- EIF2 Signaling
- CXCR4 Signaling
- FLT3 Signaling in Hematopoietic Progenitor Cells
- Colorectal Cancer Metastasis Signaling
- HGF Signaling
- Axonal Guidance Signaling
- Oncostatin M Signaling
- Neuregulin Signaling
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- Integrin Signaling
- Semaphorin Signaling in Neurons
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- α-Adrenergic Signaling
- Synaptic Long Term Depression
- FGF Signaling
- Chronic Myeloid Leukemia Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- Primary Immunodeficiency Signaling
- HMGB1 Signaling
- PPAR Signaling
- Calcium Signaling
- Chemokine Signaling
- IL-6 Signaling
- Endometrial Cancer Signaling
- Natural Killer Cell Signaling
- Agrin Interactions at Neuromuscular Junction
- Molecular Mechanisms of Cancer
- IL-17 Signaling
- Amyloid Processing
- IL-2 Signaling
- Ceramide Signaling
- CDK5 Signaling
- Melanocyte Development and Pigmentation Signaling
- Apoptosis Signaling
- Thrombin Signaling
- IL-15 Signaling
- Glioma Signaling
- NRF2-mediated Oxidative Stress Response
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Thyroid Cancer Signaling
- PI3K/AKT Signaling
- Type II Diabetes Mellitus Signaling
- IL-8 Signaling
- Acute Myeloid Leukemia Signaling
- Glucocorticoid Receptor Signaling
- TGF-β Signaling
- Non-Small Cell Lung Cancer Signaling
- IL-3 Signaling
- VEGF Signaling
- Dendritic Cell Maturation
- Insulin Receptor Signaling
- TREM1 Signaling
- JAK/Stat Signaling
- PTEN Signaling
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- B Cell Receptor Signaling
- T Cell Receptor Signaling
- Sphingosine-1-phosphate Signaling
- Melanoma Signaling
- Role of NFAT in Regulation of the Immune Response
- ILK Signaling
Protein Domains
Alcohol group acceptor phosphotransferase, ATP binding, kinase, MAP kinase, protein binding, Protein kinase, protein serine/threonine kinase, transcription factor
Subcellular Locations
cytoplasm, cytoplasmic fraction, cytoskeletal fraction, cytoskeleton, cytosol, cytosolic fraction, meiotic spindles, mitochondria, nucleus, soluble fraction
