NOTCH1 - Notch homolog 1, translocation-associated (Drosophila)
Entrez Gene Name: Notch homolog 1, translocation-associated (Drosophila)
Entrez GeneID: Human(4851)
, Mouse(18128), Rat(25496)
, Mouse(18128), Rat(25496) Synonyms: 9930111A19Rik, hN1, lin-12, Mis6, NICD, NOTCH, NOTCH1, TAN1
Gene Summary
- Human (4851): This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development. [provided by RefSeq]
- Rat (25496): transmembrane receptor; involved in cell-cell interactions important for development and pattern formation [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
anagen, axonogenesis, branching morphogenesis of a tube, cell differentiation, cell fate commitment, cell fate specification, compartment specification, determination of left/right symmetry, embryonic development, embryonic hindlimb morphogenesis, embryonic limb morphogenesis, endoderm development, epidermis development, epithelial to mesenchymal transition, forebrain development, foregut morphogenesis, glial cell differentiation, hair follicle morphogenesis, heart development, immune response, keratinocyte differentiation, liver development, lung development, multicellular organismal development, negative regulation of apoptosis, negative regulation of cell differentiation, negative regulation of myoblast differentiation, negative regulation of neuron differentiation, negative regulation of photoreceptor cell differentiation, neuron differentiation, neuron fate commitment, Notch signaling pathway, oligodendrocyte differentiation, positive regulation of apoptosis, positive regulation of cell proliferation, positive regulation of glial cell differentiation, positive regulation of keratinocyte differentiation, positive regulation of transcription from RNA polymerase II promoter, positive regulation of transcription of Notch receptor target, positive regulation of transcription, DNA-dependent, regulation of developmental process, regulation of epithelial cell proliferation, regulation of gene expression, regulation of neurogenesis, regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-dependent, somatic stem cell division, spermatogenesis, sprouting angiogenesis, tissue regeneration, transcription
Cellular Components
acrosomal vesicle, cytoplasm, Golgi apparatus, integral to membrane, integral to plasma membrane, membrane, nucleus, plasma membrane
Literature References
- 17646409O'neil J, Grim J, Strack P, Rao S, Tibbitts D, Winter C, Hardwick J, Welcker M, Meijerink JP, Pieters R, Draetta G, Sears R, Clurman BE, Look AT. FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to {gamma}-secretase inhibitors.J Exp Med 2007 Aug 06;204(8):1813-24
- 17646408Thompson BJ, Buonamici S, Sulis ML, Palomero T, Vilimas T, Basso G, Ferrando A, Aifantis I. The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia.J Exp Med 2007 Aug 06;204(8):1825-35
- 17344417Lefort K, Mandinova A, Ostano P, Kolev V, Calpini V, Kolfschoten I, Devgan V, Lieb J, Raffoul W, Hohl D, Neel V, Garlick J, Chiorino G, Dotto GP. Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCK{alpha} kinases.Genes Dev 2007 Mar 01;21(5):562-77 View 2378 categorized literature findings and their references in IPA
Molecular Functions
calcium ion binding, chromatin binding, chromatin DNA binding, metal ion binding, protein binding, receptor activity, sequence-specific DNA binding, transcription activator activity, transcription factor activity
Protein Domains
ankyrin repeat, chromatin binding, cytoplasmic domain, Delta Serate Lag-2 domain, ectodomain, EGF-like domain, extracellular domain, intracellular domain, nuclear localization sequence, opa repeat, PEST domain, protein binding, RAM domain, transcription activation domain, transcription factor, transcription regulator, transcriptional activator, transmembrane domain
Subcellular Locations
cell surface, cellular membrane, cytoplasm, cytosol, intracellular space, junctional complexes, lateral plasma membrane, membrane compartment, membrane surface, nuclear fraction, nucleus, perinuclear region, plasma membrane
