DNMT1 - DNA (cytosine-5-)-methyltransferase 1
Entrez Gene Name: DNA (cytosine-5-)-methyltransferase 1
Entrez GeneID: Human(1786)
, Mouse(13433), Rat(84350)
, Mouse(13433), Rat(84350) Synonyms: AIM, CXXC9, Cytosine 5-methyltransferase, DMT, DNA METHYLTRANSFERASE 1, DNA MTASE, DNA MTase HsaI, DNMT, DNMT1, Dnmt1o, FLJ16293, MCMT, Met-1, MGC104992, MommeD2, MTase
Gene Summary
- Human (1786): DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
- Rat (84350): methylates genomic DNA; involved in processes of gene inactivation, chromatin organization, X chromosome inactivation and genomic imprinting [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
DNA methylation, DNA methylation on cytosine within a CG sequence, gene silencing, maintenance of DNA methylation, negative regulation of transcription from RNA polymerase II promoter, negative regulation of transcription, DNA-dependent, regulation of cell proliferation, regulation of gene expression, regulation of transcription, DNA-dependent, S-adenosylhomocysteine metabolic process, S-adenosylmethioninamine metabolic process, S-adenosylmethionine metabolic process, transcription
Literature References
- 17470536Smallwood A, Estève PO, Pradhan S, Carey M. Functional cooperation between HP1 and DNMT1 mediates gene silencing.Genes Dev 2007 May 15;21(10):1169-78
- 12145218Kim GD, Ni J, Kelesoglu N, Roberts RJ, Pradhan S. Co-operation and communication between the human maintenance and de novo DNA (cytosine-5) methyltransferases.EMBO J 2002 Aug 1;21(15):4183-95
- 11847125Pradhan S, Kim GD. The retinoblastoma gene product interacts with maintenance human DNA (cytosine-5) methyltransferase and modulates its activity.EMBO J 2002 Feb 15;21(4):779-88 View 1108 categorized literature findings and their references in IPA
Molecular Functions
catalytic activity, DNA (cytosine-5-)-methyltransferase activity, DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates, DNA binding, double-stranded DNA binding, metal ion binding, methyl-CpG binding, methyltransferase activity, protein binding, protein domain specific binding, S-adenosylmethionine-dependent methyltransferase activity, transcription factor binding, transcription repressor activity, transferase activity, unmethylated CpG binding, zinc ion binding
Protein Domains
BAH domain, CXXC zinc finger, DNA (cytosine-5-)-methyltransferase, DNA binding, double-stranded DNA binding, enzyme, methyl-CpG binding, Methyltransferase, protein binding, protein domain specific binding, S-adenosylmethionine-dependent methyltransferase, transcriptional repressor, unmethylated CpG binding, zinc ion binding
Subcellular Locations
cytoplasm, DNA replication foci, nuclear foci, nuclear fraction, nuclear matrix, nucleolar fraction, nucleoli, nucleoplasm, nucleus
