MTOR - mechanistic target of rapamycin (serine/threonine kinase)
Entrez Gene Name: mechanistic target of rapamycin (serine/threonine kinase)
Entrez GeneID: Human(2475)
, Mouse(56717), Rat(56718)
, Mouse(56717), Rat(56718) Synonyms: 2610315D21Rik, AI327068, Flat, Flat-Top, FLJ44809, FRAP, FRAP1, FRAP2, FRB, MGC118056, MTOR, RAFT1, RAPT1, RRAFT1
Gene Summary
- Human (2475): The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq]
- Rat (56718): binds the complex formed by the immunosuppressive drug rapamycin and its receptor FKBP12; may play a role in the cell cycle G1 to S transition [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
cell growth, cell projection organization, G1/S transition of mitotic cell cycle, germ cell development, negative regulation of cell size, negative regulation of macroautophagy, peptidyl-threonine phosphorylation, positive regulation of actin filament polymerization, positive regulation of endothelial cell proliferation, positive regulation of lamellipodium assembly, positive regulation of peptidyl-tyrosine phosphorylation, positive regulation of protein kinase B signaling cascade, positive regulation of stress fiber formation, positive regulation of translation, protein amino acid autophosphorylation, protein amino acid phosphorylation, protein catabolic process, regulation of carbohydrate metabolic process, regulation of carbohydrate utilization, regulation of fatty acid beta-oxidation, regulation of glycogen biosynthetic process, regulation of protein kinase activity, regulation of Rac GTPase activity, regulation of response to food, response to amino acid stimulus, response to insulin stimulus, response to nutrient, ruffle organization, signal transduction
Cellular Components
cell soma, cytoplasm, cytosol, dendrite, membrane, nucleus, phosphoinositide 3-kinase complex, soluble fraction, TORC1 complex, TORC2 complex
Literature References
- 12150925Kim DH, Sarbassov DD, Ali SM, King JE, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM. mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.Cell 2002 Jul 26;110(2):163-75
- 11357143Blume-Jensen P, Hunter T. Oncogenic kinase signalling.Nature 2001 May 17;411(6835):355-65
- 11297505Gingras AC, Raught B, Sonenberg N. Regulation of translation initiation by FRAP/mTOR.Genes Dev 2001 Apr 1;15(7):807-26 View 1709 categorized literature findings and their references in IPA
Molecular Functions
binding, drug binding, kinase activity, phosphoprotein binding, phosphotransferase activity, alcohol group as acceptor, protein binding, protein serine/threonine kinase activity, transferase activity, transferase activity, transferring phosphorus-containing groups
- Acute Myeloid Leukemia Signaling
- Huntington's Disease Signaling
- ILK Signaling
- Prostate Cancer Signaling
- B Cell Receptor Signaling
- TR/RXR Activation
- Insulin Receptor Signaling
- AMPK Signaling
- Glioma Signaling
- FLT3 Signaling in Hematopoietic Progenitor Cells
- mTOR Signaling
- CNTF Signaling
- Acute Phase Response Signaling
- p70S6K Signaling
- Systemic Lupus Erythematosus Signaling
- Neuregulin Signaling
- PI3K/AKT Signaling
- Type II Diabetes Mellitus Signaling
- JAK/Stat Signaling
- IL-4 Signaling
- Cardiac Hypertrophy Signaling
- IL-8 Signaling
Protein Domains
activation domain, carboxy terminal domain, drug binding, FAT domain, FATC domain, HEAT repeat, kinase, kinase domain, phosphatidic acid binding domain, protein binding, Protein kinase, protein serine/threonine kinase
Subcellular Locations
cell body, cellular membrane, cytoplasm, cytoskeletal fraction, cytosol, cytosolic fraction, dendrites, endoplasmic reticulum, extracellular space, Golgi apparatus, high-density microsomal fractions, low-density microsomal fraction, membrane fraction, mitochondria, nucleus, perinuclear region, presynaptic membrane, sarcolemma, synapse, synaptic vesicles, synaptosomes
