SP1 - Sp1 transcription factor
Entrez Gene Name: Sp1 transcription factor
Entrez GeneID: Human(6667)
, Mouse(20683), Rat(24790)
, Mouse(20683), Rat(24790) Synonyms: 1110003E12RIK, AA450830, AI845540, SP1, Sp1 (trans spliced isoform), SP1-1, Trans-acting transcription factor 1
Gene Summary
- Rat (24790): transcription factor that recognizes 5'-CCGCCC promoter sequence; plays a role in transcriptional regulation of many genes [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
definitive hemopoiesis, embryonic camera-type eye morphogenesis, embryonic placenta development, embryonic process involved in female pregnancy, embryonic skeletal system development, enucleate erythrocyte differentiation, in utero embryonic development, interspecies interaction between organisms, liver development, lung development, megakaryocyte differentiation, ossification, positive regulation of transcription from RNA polymerase II promoter, positive regulation of transcription from RNA polymerase II promoter, global, positive regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-dependent, transcription, trophectodermal cell differentiation
Literature References
- 11988536Dunah AW, Jeong H, Griffin A, Kim YM, Standaert DG, Hersch SM, Mouradian MM, Young AB, Tanese N, Krainc D. Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease.Science 2002 Jun 21;296(5576):2238-43
- 11598016Fojas de Borja P, Collins NK, Du P, Azizkhan-Clifford J, Mudryj M. Cyclin A-CDK phosphorylates Sp1 and enhances Sp1-mediated transcription.EMBO J 2001 Oct 15;20(20):5737-47
- 11013220Feng XH, Lin X, Derynck R. Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta.EMBO J 2000 Oct 2;19(19):5178-93 View 4207 categorized literature findings and their references in IPA
Molecular Functions
DNA binding, double-stranded DNA binding, metal ion binding, nucleic acid binding, protein binding, protein C-terminus binding, protein homodimerization activity, RNA polymerase II transcription factor activity, sequence-specific DNA binding, transcription activator activity, transcription factor activity, zinc ion binding
Protein Domains
activation domain, C2H2 zinc finger domain, DNA binding, double-stranded DNA binding, Glutamine-rich domain, N-terminal domain, protein binding, protein C-terminus binding, protein homodimerization, Sp1 D domain, transcription activation domain, transcription factor, transcription regulator, transcriptional activator, Zinc finger domain
Subcellular Locations
cytoplasm, cytosol, membrane fraction, nuclear fraction, nuclear matrix, nuclear matrix fraction, nucleoplasm, nucleus, soluble fraction
