CDC42 - cell division cycle 42 (GTP binding protein, 25kDa)
Entrez Gene Name: cell division cycle 42 (GTP binding protein, 25kDa)
Entrez GeneID: Human(998)
Synonyms: AI747189, AU018915, CDC42, CDC42HS, CELLULAR GROWTH REGULATING, G25K
Gene Summary
- Human (998): The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
actin cytoskeleton organization, establishment or maintenance of cell polarity, macrophage differentiation, negative regulation of protein complex assembly, positive regulation of pseudopodium assembly, small GTPase mediated signal transduction
Literature References
- 16169070Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE. A human protein-protein interaction network: a resource for annotating the proteome.Cell 2005 Sep 23;122(6):957-68
- 15630019Govek EE, Newey SE, Van Aelst L. The role of the Rho GTPases in neuronal development.Genes Dev 2005 01 1;19(1):1-49
- 11807174Juliano RL. Signal transduction by cell adhesion receptors and the cytoskeleton: functions of integrins, cadherins, selectins, and immunoglobulin-superfamily members.Annu Rev Pharmacol Toxicol 2002;42:283-323 View 3000 categorized literature findings and their references in IPA
- Pancreatic Adenocarcinoma Signaling
- Cdc42 Signaling
- Regulation of Actin-based Motility by Rho
- GNRH Signaling
- Virus Entry via Endocytic Pathways
- CD28 Signaling in T Helper Cells
- Clathrin-mediated Endocytosis Signaling
- Molecular Mechanisms of Cancer
- Gα12/13 Signaling
- Renal Cell Carcinoma Signaling
- SAPK/JNK Signaling
- ILK Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- PTEN Signaling
- G Beta Gamma Signaling
- Actin Cytoskeleton Signaling
- Tight Junction Signaling
- Integrin Signaling
- HMGB1 Signaling
- Ephrin Receptor Signaling
- Neurotrophin/TRK Signaling
- HGF Signaling
- B Cell Receptor Signaling
- Agrin Interactions at Neuromuscular Junction
- fMLP Signaling in Neutrophils
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- Leukocyte Extravasation Signaling
- LPS-stimulated MAPK Signaling
- Axonal Guidance Signaling
- Macropinocytosis Signaling
Subcellular Locations
actin bundles, cell membrane leading edge, cell periphery, cellular membrane, cytoplasm, cytoplasmic particles, cytosol, cytosolic fraction, exosomes, Golgi apparatus, granules, membrane ruffles, microtubule organizing centers, perinuclear membrane, perinuclear region, plasma membrane, podosomes, soluble fraction
