AKT1 - v-akt murine thymoma viral oncogene homolog 1
Entrez Gene Name: v-akt murine thymoma viral oncogene homolog 1
Entrez GeneID: Human(207)
, Mouse(11651)
, Rat(24185)
Synonyms: AKT, AKT1, MGC99656, PKB, PKB-ALPHA, PKB/AKT, PRKBA, Protein kinase B, RAC, RAC-ALPHA, Thymoma viral proto-oncogene 1
Gene Summary
- Human (207): The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]
- Rat (24185): inhibits JUN kinase activation and mediates inhibition of apoptosis [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
activation of pro-apoptotic gene products, activation-induced cell death of T cells, anagen, anti-apoptosis, apoptosis, apoptotic mitochondrial changes, blood vessel development, carbohydrate metabolic process, carbohydrate transport, cell projection organization, cellular response to insulin stimulus, G-protein coupled receptor protein signaling pathway, germ cell development, glucose metabolic process, glucose transport, glycogen biosynthetic process, glycogen metabolic process, inflammatory response, insulin receptor signaling pathway, insulin-like growth factor receptor signaling pathway, intracellular signaling cascade, negative regulation of apoptosis, negative regulation of cell size, negative regulation of fatty acid beta-oxidation, negative regulation of JNK cascade, negative regulation of plasma membrane long-chain fatty acid transport, negative regulation of protein kinase activity, peptidyl-serine phosphorylation, placenta development, positive regulation of cell growth, positive regulation of cellular protein metabolic process, positive regulation of cyclin-dependent protein kinase activity during G1/S, positive regulation of fat cell differentiation, positive regulation of glucose import, positive regulation of glucose metabolic process, positive regulation of glycogen biosynthetic process, positive regulation of lipid biosynthetic process, positive regulation of multicellular organism growth, positive regulation of nitric oxide biosynthetic process, positive regulation of nitric-oxide synthase activity, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of sodium ion transport, protein amino acid autophosphorylation, protein amino acid phosphorylation, protein catabolic process, protein import into nucleus, translocation, protein kinase B signaling cascade, protein modification process, protein ubiquitination, regulation of cell migration, regulation of establishment of protein localization, regulation of protein localization, regulation of survival gene product expression, regulation of translation, response to fluid shear stress, response to food, response to heat, response to hormone stimulus, response to UV-A, signal transduction, transport
Cellular Components
cytoplasm, cytoskeleton, cytosol, lamellipodium, membrane, nucleoplasm, nucleus, plasma membrane, soluble fraction, spindle
Literature References
- 17932490
Cinar B, Fang PK, Lutchman M, Di Vizio D, Adam RM, Pavlova N, Rubin MA, Yelick PC, Freeman MR. The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1.EMBO J 2007 10 31;26(21):4523-34 - 16177823
Hu Y, Yao J, Liu Z, Liu X, Fu H, Ye K. Akt phosphorylates acinus and inhibits its proteolytic cleavage, preventing chromatin condensation.EMBO J 2005 Oct 19;24(20):3543-54 - 16051150
Beaulieu JM, Sotnikova TD, Marion S, Lefkowitz RJ, Gainetdinov RR, Caron MG. An Akt/beta-Arrestin 2/PP2A Signaling Complex Mediates Dopaminergic Neurotransmission and Behavior.Cell 2005 Jul 29;122(2):261-73 View 12746 categorized literature findings and their references in IPA
Molecular Functions
ATP binding, enzyme binding, identical protein binding, kinase activity, nitric-oxide synthase regulator activity, nucleotide binding, phosphatidylinositol-3,4,5-trisphosphate binding, phosphatidylinositol-3,4-bisphosphate binding, protein binding, protein kinase activity, protein serine/threonine kinase activity, sugar:hydrogen symporter activity, transferase activity
- Tight Junction Signaling
- ERK5 Signaling
- TR/RXR Activation
- Lymphotoxin β Receptor Signaling
- Wnt/β-catenin Signaling
- NRF2-mediated Oxidative Stress Response
- PI3K/AKT Signaling
- FAK Signaling
- Erythropoietin Signaling
- G-Protein Coupled Receptor Signaling
- Glioma Signaling
- CXCR4 Signaling
- PTEN Signaling
- p70S6K Signaling
- IL-22 Signaling
- TREM1 Signaling
- Role of PKR in Interferon Induction and Antiviral Response
- IL-17 Signaling
- Role of NFAT in Regulation of the Immune Response
- FLT3 Signaling in Hematopoietic Progenitor Cells
- IL-12 Signaling and Production in Macrophages
- Glucocorticoid Receptor Signaling
- Prostate Cancer Signaling
- FcγRIIB Signaling in B Lymphocytes
- RAR Activation
- ILK Signaling
- B Cell Receptor Signaling
- Amyloid Processing
- Acute Myeloid Leukemia Signaling
- FXR/RXR Activation
- 14-3-3-mediated Signaling
- p53 Signaling
- IL-3 Signaling
- IL-15 Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Nitric Oxide Signaling in the Cardiovascular System
- Endometrial Cancer Signaling
- HIF1α Signaling
- Fc Epsilon RI Signaling
- G Beta Gamma Signaling
- JAK/Stat Signaling
- Ceramide Signaling
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Acute Phase Response Signaling
- EIF2 Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Integrin Signaling
- Melanoma Signaling
- FGF Signaling
- Pancreatic Adenocarcinoma Signaling
- Huntington's Disease Signaling
- IL-4 Signaling
- Angiopoietin Signaling
- CD28 Signaling in T Helper Cells
- NF-κB Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- CREB Signaling in Neurons
- CTLA4 Signaling in Cytotoxic T Lymphocytes
- Hypoxia Signaling in the Cardiovascular System
- Relaxin Signaling
- Renal Cell Carcinoma Signaling
- Human Embryonic Stem Cell Pluripotency
- Myc Mediated Apoptosis Signaling
- Chronic Myeloid Leukemia Signaling
- Non-Small Cell Lung Cancer Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- Thrombin Signaling
- NF-κB Activation by Viruses
- VEGF Signaling
- Natural Killer Cell Signaling
- Insulin Receptor Signaling
- Dendritic Cell Maturation
- HGF Signaling
- Sphingosine-1-phosphate Signaling
- Gα12/13 Signaling
- IGF-1 Signaling
- Neurotrophin/TRK Signaling
- iCOS-iCOSL Signaling in T Helper Cells
- Neuregulin Signaling
- Systemic Lupus Erythematosus Signaling
- Type II Diabetes Mellitus Signaling
- AMPK Signaling
- IL-8 Signaling
- CNTF Signaling
- Reelin Signaling in Neurons
- PXR/RXR Activation
- Colorectal Cancer Metastasis Signaling
- Molecular Mechanisms of Cancer
- mTOR Signaling
- IL-2 Signaling
- GM-CSF Signaling
- Cardiac Hypertrophy Signaling
- Ephrin Receptor Signaling
- HMGB1 Signaling
- Small Cell Lung Cancer Signaling
- Axonal Guidance Signaling
Protein Domains
hydrophobic domain, kinase, myristoylation signal domain, nitric oxide synthase regulator, pleckstrin homology (PH) domain, protein binding, Protein kinase, protein self binding, protein serine/threonine kinase, regulatory domain
Subcellular Locations
brush border, cell body, cell membrane leading edge, cytoplasm, cytosol, cytosolic fraction, dendrites, dendritic shafts, high-density microsomal fractions, low-density microsomal fraction, membrane fraction, membrane rafts, neurites, nucleus, plasma membrane, plasma membrane fraction, raft fractions, smooth endoplasmatic reticulum, spine apparatus



