PIK3CA - phosphoinositide-3-kinase, catalytic, alpha polypeptide
Entrez Gene Name: phosphoinositide-3-kinase, catalytic, alpha polypeptide
Entrez GeneID: Human(5290)
, Mouse(18706), Rat(170911)
, Mouse(18706), Rat(170911) Synonyms: 6330412C24RIK, caPI3K, MGC116320, MGC142161, MGC142163, MGC161268, P110, P110 ALPHA, PI3K, PI3K-ALPHA, Pi3kca, PIK3CA
Gene Summary
- Human (5290): Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. [provided by RefSeq]
- Rat (170911): expression of the human homolog is associated with increased cell proliferation and decreased apoptosis and may play a role in ovarian cancer progression [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
anti-apoptosis, glucose metabolic process, negative regulation of apoptosis, phosphoinositide phosphorylation, phosphoinositide-mediated signaling, protein amino acid phosphorylation, protein kinase B signaling cascade, regulation of multicellular organism growth, signal transduction
Cellular Components
cytoplasm, cytosol, lamellipodium, mitochondrion, phosphoinositide 3-kinase complex
Literature References
- 12598680Segal RA. Selectivity in neurotrophin signaling: theme and variations.Annu Rev Neurosci 2003 Jan 01;26:299-330
- 12356726Arcaro A, Khanzada UK, Vanhaesebroeck B, Tetley TD, Waterfield MD, Seckl MJ. Two distinct phosphoinositide 3-kinases mediate polypeptide growth factor-stimulated PKB activation.EMBO J 2002 Oct 1;21(19):5097-5108
- 11959846Singh B, Reddy PG, Goberdhan A, Walsh C, Dao S, Ngai I, Chou TC, O-Charoenrat P, Levine AJ, Rao PH, Stoffel A. p53 regulates cell survival by inhibiting PIK3CA in squamous cell carcinomas.Genes Dev 2002 Apr 15;16(8):984-93 View 4227 categorized literature findings and their references in IPA
Molecular Functions
1-phosphatidylinositol-3-kinase activity, ATP binding, binding, inositol or phosphatidylinositol kinase activity, insulin receptor substrate binding, kinase activity, nucleotide binding, phosphatidylinositol-4,5-bisphosphate 3-kinase activity, phosphotransferase activity, alcohol group as acceptor, transferase activity
- Fc Epsilon RI Signaling
- NF-κB Signaling
- Non-Small Cell Lung Cancer Signaling
- Chronic Myeloid Leukemia Signaling
- Glucocorticoid Receptor Signaling
- IL-15 Signaling
- Small Cell Lung Cancer Signaling
- IL-8 Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- B Cell Receptor Signaling
- Huntington's Disease Signaling
- Neurotrophin/TRK Signaling
- Leukocyte Extravasation Signaling
- ILK Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- FGF Signaling
- EIF2 Signaling
- Endometrial Cancer Signaling
- IL-17 Signaling
- Prolactin Signaling
- Clathrin-mediated Endocytosis Signaling
- Prostate Cancer Signaling
- RAR Activation
- G-Protein Coupled Receptor Signaling
- Ceramide Signaling
- Thrombin Signaling
- SAPK/JNK Signaling
- Natural Killer Cell Signaling
- LPS-stimulated MAPK Signaling
- p53 Signaling
- CNTF Signaling
- NF-κB Activation by Viruses
- iCOS-iCOSL Signaling in T Helper Cells
- Reelin Signaling in Neurons
- IGF-1 Signaling
- Sphingosine-1-phosphate Signaling
- Insulin Receptor Signaling
- Endothelin-1 Signaling
- CTLA4 Signaling in Cytotoxic T Lymphocytes
- Human Embryonic Stem Cell Pluripotency
- Aldosterone Signaling in Epithelial Cells
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- AMPK Signaling
- CCR3 Signaling in Eosinophils
- HIF1α Signaling
- TR/RXR Activation
- Melanoma Signaling
- Cardiac Hypertrophy Signaling
- Acute Myeloid Leukemia Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Axonal Guidance Signaling
- Type II Diabetes Mellitus Signaling
- Role of NFAT in Regulation of the Immune Response
- CXCR4 Signaling
- ERK/MAPK Signaling
- Molecular Mechanisms of Cancer
- Inositol Phosphate Metabolism
- Angiopoietin Signaling
- Growth Hormone Signaling
- PI3K/AKT Signaling
- HGF Signaling
- Colorectal Cancer Metastasis Signaling
- Amyotrophic Lateral Sclerosis Signaling
- NRF2-mediated Oxidative Stress Response
- PTEN Signaling
- Virus Entry via Endocytic Pathways
- CD28 Signaling in T Helper Cells
- CD40 Signaling
- Systemic Lupus Erythematosus Signaling
- JAK/Stat Signaling
- Gα12/13 Signaling
- Macropinocytosis Signaling
- Myc Mediated Apoptosis Signaling
- 14-3-3-mediated Signaling
- Relaxin Signaling
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- Glioma Signaling
- HMGB1 Signaling
- IL-3 Signaling
- p70S6K Signaling
- Antiproliferative Role of Somatostatin Receptor 2
- IL-4 Signaling
- Melanocyte Development and Pigmentation Signaling
- T Cell Receptor Signaling
- Integrin Signaling
- Acute Phase Response Signaling
- Lymphotoxin β Receptor Signaling
- PDGF Signaling
- Pancreatic Adenocarcinoma Signaling
- Renal Cell Carcinoma Signaling
- Dendritic Cell Maturation
- Nitric Oxide Signaling in the Cardiovascular System
- IL-2 Signaling
- Actin Cytoskeleton Signaling
- EGF Signaling
- FLT3 Signaling in Hematopoietic Progenitor Cells
- CREB Signaling in Neurons
- Erythropoietin Signaling
- fMLP Signaling in Neutrophils
- FAK Signaling
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- GM-CSF Signaling
- Renin-Angiotensin Signaling
- VEGF Signaling
- IL-9 Signaling
- IL-12 Signaling and Production in Macrophages
- mTOR Signaling
- Xenobiotic Metabolism Signaling
- Thrombopoietin Signaling
- FcγRIIB Signaling in B Lymphocytes
Protein Domains
C2 domain, kinase, N-terminal domain, p85 binding domain, Phosphatidylinositol 3-kinase, Phosphatidylinositol-4,5-bisphosphate 3-kinase, PIK domain, protein binding, Ras-binding domain
Subcellular Locations
cell-cell contacts, cytoplasm, cytosol, filopodia, membrane compartment, microsomal membrane, plasma membrane
