CREB1 - cAMP responsive element binding protein 1
Entrez Gene Name: cAMP responsive element binding protein 1
Entrez GeneID: Human(1385)
, Mouse(12912), Rat(81646)
, Mouse(12912), Rat(81646) Synonyms: 2310001E10Rik, 3526402H21RIK, AV083133, CAMP RESPONSE ELEMENT BINDING PROTEIN 1, Cbp, CREB, CREB1, MGC9284, X2BP
Gene Summary
- Human (1385): This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq]
- Rat (81646): binds the cAMP response element in many gene promoters and regulates transcription [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
axonogenesis, interspecies interaction between organisms, lactation, mammary gland development, pituitary gland development, positive regulation of hormone secretion, positive regulation of multicellular organism growth, positive regulation of specific transcription from RNA polymerase II promoter, positive regulation of transcription from RNA polymerase II promoter, positive regulation of transforming growth factor-beta3 production, protein amino acid phosphorylation, regulation of apoptosis, regulation of cell size, regulation of circadian rhythm, regulation of transcription, DNA-dependent, response to drug, response to organic substance, signal transduction, transcription, transcription from RNA polymerase II promoter, transforming growth factor beta receptor signaling pathway
Literature References
- 16169070Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE. A human protein-protein interaction network: a resource for annotating the proteome.Cell 2005 Sep 23;122(6):957-68
- 12805224Mendez-Pertuz M, Sanchez-Pacheco A, Aranda A. The thyroid hormone receptor antagonizes CREB-mediated transcription.EMBO J 2003 Jun 16;22(12):3102-12
- 11988169Lonze BE, Riccio A, Cohen S, Ginty DD. Apoptosis, axonal growth defects, and degeneration of peripheral neurons in mice lacking CREB.Neuron 2002 Apr 25;34(3):371-85 View 4379 categorized literature findings and their references in IPA
Molecular Functions
DNA binding, double-stranded DNA binding, protein binding, protein dimerization activity, RNA polymerase II transcription factor activity, enhancer binding, sequence-specific DNA binding, specific RNA polymerase II transcription factor activity, transcription cofactor activity, transcription factor activity
- FLT3 Signaling in Hematopoietic Progenitor Cells
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- B Cell Receptor Signaling
- FGF Signaling
- cAMP-mediated Signaling
- ERK/MAPK Signaling
- Prostate Cancer Signaling
- Cardiac Hypertrophy Signaling
- Neurotrophin/TRK Signaling
- GNRH Signaling
- p38 MAPK Signaling
- Circadian Rhythm Signaling
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- ATM Signaling
- LPS-stimulated MAPK Signaling
- Dendritic Cell Maturation
- Corticotropin Releasing Hormone Signaling
- Relaxin Signaling
- ERK5 Signaling
- Thrombin Signaling
- Ephrin Receptor Signaling
- Calcium Signaling
- Melanocyte Development and Pigmentation Signaling
- G-Protein Coupled Receptor Signaling
- Synaptic Long Term Potentiation
- Huntington's Disease Signaling
- Hypoxia Signaling in the Cardiovascular System
- ILK Signaling
- BMP signaling pathway
- Glucocorticoid Receptor Signaling
- CREB Signaling in Neurons
Protein Domains
bZIP domain, DNA binding, DNA binding domain, double-stranded DNA binding, kinase-inducible domain, leucine zipper domain, promoter-specific RNA polymerase II transcription factor, protein binding, transcription activation domain, transcription cofactor, transcription factor, transcription factor, DNA binding, transcription regulator
