EGFR - epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
Entrez Gene Name: epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
Entrez GeneID: Human(1956)
, Mouse(13649), Rat(24329)
, Mouse(13649), Rat(24329) Synonyms: 9030024J15RIK, AI552599, EGF RECEPTOR, EGF-TK, EGFR, EGFR1, EGFRec, ER2, ERBB, ERBB1, Errp, HER1, MENA, PIG61, wa-2, Wa5
Gene Summary
- Human (1956): The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq]
- Rat (24329): promotes cell proliferation and differentiation; mediates GPCR regulated induction of protein synthesis [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
activation of MAPKK activity, activation of phospholipase A2 activity by calcium-mediated signaling, activation of phospholipase C activity, astrocyte activation, cell morphogenesis, cell surface receptor linked signal transduction, cell-cell adhesion, circadian rhythm, epidermal growth factor receptor signaling pathway, negative regulation of apoptosis, negative regulation of cell cycle, negative regulation of mitotic cell cycle, neuron projection morphogenesis, ossification, ovulation cycle, positive regulation of cell migration, positive regulation of cell proliferation, positive regulation of cyclin-dependent protein kinase activity during G1/S, positive regulation of epithelial cell proliferation, positive regulation of MAP kinase activity, positive regulation of nitric oxide biosynthetic process, positive regulation of phosphorylation, positive regulation of smooth muscle cell proliferation, positive regulation of synaptic transmission, glutamatergic, protein amino acid autophosphorylation, protein amino acid phosphorylation, protein insertion into membrane, protein kinase cascade, regulation of cell proliferation, regulation of nitric-oxide synthase activity, regulation of peptidyl-tyrosine phosphorylation, response to calcium ion, response to lipid, response to osmotic stress, response to oxidative stress, response to stress, response to UV-A, salivary gland morphogenesis, signal transduction, tongue development, translation, transmembrane receptor protein tyrosine kinase signaling pathway
Cellular Components
AP-2 adaptor complex, apical plasma membrane, basolateral plasma membrane, cytoplasm, endocytic vesicle, endoplasmic reticulum, endosome, extracellular region, extracellular space, integral to membrane, intracellular, membrane, nucleus, plasma membrane, Shc-EGFR complex
Literature References
- 16705038Politi K, Zakowski MF, Fan PD, Schonfeld EA, Pao W, Varmus HE. Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors.Genes Dev 2006 Jun 01;20(11):1496-510
- 16273093Jones RB, Gordus A, Krall JA, MacBeath G. A quantitative protein interaction network for the ErbB receptors using protein microarrays.Nature 2006 01 12;439(7073):168-74
- 14570567Hicke L, Dunn R. Regulation of membrane protein transport by ubiquitin and ubiquitin-binding proteins.Annu Rev Cell Dev Biol 2003 Jan 01;19:141-72 View 8814 categorized literature findings and their references in IPA
Molecular Functions
actin filament binding, ATP binding, double-stranded DNA binding, epidermal growth factor receptor activity, identical protein binding, kinase activity, MAP/ERK kinase kinase activity, nitric-oxide synthase regulator activity, nucleotide binding, protein binding, protein heterodimerization activity, protein kinase activity, protein phosphatase binding, protein tyrosine kinase activity, receptor activity, signal transducer activity, transferase activity, transmembrane receptor activity, transmembrane receptor protein tyrosine kinase activity
- Caveolar-mediated Endocytosis Signaling
- IL-8 Signaling
- GNRH Signaling
- Neuregulin Signaling
- EGF Signaling
- Thrombin Signaling
- NF-κB Signaling
- PTEN Signaling
- p70S6K Signaling
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- G Beta Gamma Signaling
- FAK Signaling
- ERK5 Signaling
- Glioma Signaling
- Cholecystokinin/Gastrin-mediated Signaling
- Pancreatic Adenocarcinoma Signaling
- Colorectal Cancer Metastasis Signaling
- Huntington's Disease Signaling
- Bladder Cancer Signaling
- Non-Small Cell Lung Cancer Signaling
- Agrin Interactions at Neuromuscular Junction
Protein Domains
cytoplasmic kinase domain, epidermal growth factor receptor, extracellular domain, Furin-like cysteine rich domain, kinase, L domain, nitric oxide synthase regulator, protein binding, protein heterodimerization, protein self binding, protein-tyrosine kinase, signal transducer, transmembrane domain, transmembrane receptor, tyrosine kinase domain
Subcellular Locations
apical cell surfaces, apical membrane, basolateral cell surfaces, basolateral membrane, caveolae, caveolae fraction, caveolar membranes, cell periphery, cell surface, cell-associated matrix, cell-cell adherens junctions, cell-cell contacts, cellular membrane, cilia, clathrin-coated pits, clathrin-coated vesicles, cytoplasm, detergent-soluble fraction, early endosomes, endoplasmic reticulum, endosomes, extracellular space, Golgi region, intercellular junctions, late endosomes, lysosome, membrane blebs, membrane fraction, membrane rafts, membrane surface, multivesicular bodies, nuclear envelope, nuclear fraction, nucleus, perinuclear region, perinuclear space, pH resistant lipid raft fraction, plasma membrane, plasma membrane fraction, raft fractions, vesicles
