NTN1 - netrin 1
Entrez Gene Name: netrin 1
Entrez GeneID: Human(9423)
, Mouse(18208), Rat(114523)
, Mouse(18208), Rat(114523) Synonyms: AI561871, BC019633, NETRIN1, NTN1, NTN1L
Gene Summary
- Human (9423): Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression of netrin suggest that variation in netrin may be involved in cancer development. [provided by RefSeq]
- Rat (114523): plays a role in axon guidance during development; may also be involved in cell-cell interactions in the adult nervous system [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
apoptosis, axon guidance, axonogenesis, establishment of nucleus localization, mammary gland development, negative regulation of axon extension, neuron migration, positive regulation of axon extension, positive regulation of cell proliferation, regulation of cell migration
Cellular Components
basement membrane, cytoplasm, extracellular region, extracellular space, proteinaceous extracellular matrix
Literature References
- 15630019Govek EE, Newey SE, Van Aelst L. The role of the Rho GTPases in neuronal development.Genes Dev 2005 01 1;19(1):1-49
- 12670423Campbell DS, Holt CE. Apoptotic Pathway and MAPKs Differentially Regulate Chemotropic Responses of Retinal Growth Cones.Neuron 2003 Mar 27;37(6):939-952
- 8978605Serafini T, Colamarino SA, Leonardo ED, Wang H, Beddington R, Skarnes WC, Tessier-Lavigne M. Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system.Cell 1996 Dec 13;87(6):1001-14 View 460 categorized literature findings and their references in IPA
Protein Domains
carboxy terminal domain, EGF repeat, Laminin domain VI, laminin EGF-like domain, Laminin VI-like domain, protein binding
Subcellular Locations
axolemmal fraction, cell body, cell surface, extracellular space, membrane processes, neurites, periaxonal myelin membrane fraction, plasma membrane
