P2RY1 - purinergic receptor P2Y, G-protein coupled, 1
Entrez Gene Name: purinergic receptor P2Y, G-protein coupled, 1
Entrez GeneID: Human(5028)
, Mouse(18441), Rat(25265)
, Mouse(18441), Rat(25265) Synonyms: P2RY1, P2y, P2Y1, P2y1 receptor
Gene Summary
- Human (5028): The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation. [provided by RefSeq]
- Rat (25265): G protein-coupled receptor for extracellular ATP; plays a role in ischemic preconditioning (IPC) in heart [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger, blood coagulation, G-protein coupled receptor protein signaling pathway, positive regulation of ion transport, signal transduction
Cellular Components
apical plasma membrane, basolateral plasma membrane, integral to membrane, integral to plasma membrane, membrane, plasma membrane
Literature References
- 12743035Gschwind A, Hart S, Fischer OM, Ullrich A. TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells.EMBO J 2003 May 15;22(10):2411-2421
- 17215444Hohenstein B, Renk S, Lang K, Daniel C, Freund M, Léon C, Amann KU, Gachet C, Hugo CP. P2Y1 gene deficiency protects from renal disease progression and capillary rarefaction during passive crescentic glomerulonephritis.J Am Soc Nephrol 2007 Feb 01;18(2):494-505
- 15901899Fam SR, Paquet M, Castleberry AM, Oller H, Lee CJ, Traynelis SF, Smith Y, Yun CC, Hall RA. P2Y1 receptor signaling is controlled by interaction with the PDZ scaffold NHERF-2.Proc Natl Acad Sci U S A 2005 May 31;102(22):8042-7 View 371 categorized literature findings and their references in IPA
Molecular Functions
ADP binding, ATP binding, G-protein coupled receptor activity, purinergic nucleotide receptor activity, G-protein coupled, receptor activity, signal transducer activity
Protein Domains
ATP binding, G-protein coupled receptor, purinergic G-protein coupled nucleotide receptor, receptor, tail domain
Subcellular Locations
alpha granules, cell surface, cellular membrane, demarcation membrane systems, intracellular space, membrane fraction, membrane surface, plasma membrane, vesicles
