ADRA1A - adrenergic, alpha-1A-, receptor
Entrez Gene Name: adrenergic, alpha-1A-, receptor
Entrez GeneID: Human(148)
, Mouse(11549), Rat(29412)
, Mouse(11549), Rat(29412) Synonyms: a 1a, ADRA1A, ADRA1C, ADRA1L1, Adrenergic Receptor alpha1a, Alpha 1a adrenergic receptor, ALPHA-1A AR, Alpha1a adrenoceptor, Alpha1a adrenoreceptor, MGC130524
Gene Summary
- Human (148): Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq]
- Rat (29412): binds adrenergic compounds and analogs; activates phospholipase C mediated signal transduction [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
activation of phospholipase C activity, activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger, adult heart development, aging, apoptosis, cell growth, cell-cell signaling, elevation of cytosolic calcium ion concentration, G-protein coupled receptor protein signaling pathway, negative regulation of cell proliferation, negative regulation of heart rate in baroreceptor response to increased systemic arterial blood pressure, negative regulation of Rho protein signal transduction, negative regulation of synaptic transmission, GABAergic, norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure, organ growth, positive regulation of action potential, positive regulation of heart rate by epinephrine-norepinephrine, positive regulation of MAPKKK cascade, positive regulation of the force of heart contraction by epinephrine-norepinephrine, positive regulation of vasoconstriction, protein kinase cascade, response to drug, response to hormone stimulus, response to stress, signal transduction, smooth muscle contraction
Cellular Components
integral to membrane, integral to plasma membrane, membrane, membrane fraction, plasma membrane
Literature References
- 12743035Gschwind A, Hart S, Fischer OM, Ullrich A. TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells.EMBO J 2003 May 15;22(10):2411-2421
- 17283256Huang Y, Wright CD, Merkwan CL, Baye NL, Liang Q, Simpson PC, O'Connell TD. An alpha1A-adrenergic-extracellular signal-regulated kinase survival signaling pathway in cardiac myocytes.Circulation 2007 Feb 13;115(6):763-72
- 16033418Bauer A, Zilles K, Matusch A, Holzmann C, Riess O, von Hörsten S. Regional and subtype selective changes of neurotransmitter receptor density in a rat transgenic for the Huntington's disease mutation.J Neurochem 2005 Aug 01;94(3):639-50 View 1247 categorized literature findings and their references in IPA
Molecular Functions
adrenoceptor activity, alpha1-adrenergic receptor activity, G-protein coupled receptor activity, receptor activity, signal transducer activity
Subcellular Locations
cell surface, cellular membrane, endoplasmic reticulum, endoplasmic reticulum/Golgi apparatus fractions, intracellular membranes, membrane fraction, membrane rafts, membrane surface, plasma membrane
