MAPK14 - mitogen-activated protein kinase 14
Entrez Gene Name: mitogen-activated protein kinase 14
Entrez GeneID: Human(1432)
, Mouse(26416), Rat(81649)
, Mouse(26416), Rat(81649) Synonyms: CRK1, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Hog, MAPK p38, MAPK14, MGC102436, MGC105413, MXI2, P38, P38 KINASE, P38 Map Kinase, p38 Mapk alpha, P38-ALPHA, p38-RK, p38/Hog1, p38/Mpk2, P38/RK, p38a, p38Hog, p38MAPK, PRKM14, PRKM15, RK, SAPK2A
Gene Summary
- Human (1432): The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq]
- Rat (81649): mitogen-activated protein kinase; involved in intracellular signalling, inhibition of apoptosis and gene activation [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
angiogenesis, cell morphogenesis, cell motion, chemotaxis, chondrocyte differentiation, DNA damage checkpoint, fatty acid oxidation, glucose metabolic process, lipopolysaccharide-mediated signaling pathway, positive regulation of erythrocyte differentiation, positive regulation of transcription from RNA polymerase II promoter, protein amino acid autophosphorylation, protein amino acid phosphorylation, protein kinase cascade, Ras protein signal transduction, response to lipopolysaccharide, response to muramyl dipeptide, response to stress, skeletal muscle tissue development, stress-activated MAPK cascade
Cellular Components
cell, cytoplasm, cytosol, cytosolic part, nucleoplasm, nucleus, soluble fraction, spindle pole
Literature References
- 17255949Casar B, Sanz-Moreno V, Yazicioglu MN, Rodríguez J, Berciano MT, Lafarga M, Cobb MH, Crespo P. Mxi2 promotes stimulus-independent ERK nuclear translocation.EMBO J 2007 02 7;26(3):635-46
- 12065415Wang S, Zhang B, Faller DV. Prohibitin requires Brg-1 and Brm for the repression of E2F and cell growth.EMBO J 2002 Jun 17;21(12):3019-28
- 11861597Dong C, Davis RJ, Flavell RA. MAP kinases in the immune response.Annu Rev Immunol 2002;20:55-72 View 11463 categorized literature findings and their references in IPA
Molecular Functions
ATP binding, kinase activity, MAP kinase activity, MAP kinase kinase activity, MP kinase activity, nucleotide binding, protein binding, protein C-terminus binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity
- PPARα/RXRα Activation
- Renin-Angiotensin Signaling
- BMP signaling pathway
- IL-17 Signaling
- Molecular Mechanisms of Cancer
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Cholecystokinin/Gastrin-mediated Signaling
- B Cell Activating Factor Signaling
- FGF Signaling
- IL-12 Signaling and Production in Macrophages
- Fc Epsilon RI Signaling
- p53 Signaling
- Amyloid Processing
- FLT3 Signaling in Hematopoietic Progenitor Cells
- Endothelin-1 Signaling
- Role of PKR in Interferon Induction and Antiviral Response
- IL-15 Signaling
- HMGB1 Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- Dendritic Cell Maturation
- Acute Phase Response Signaling
- Cardiac Hypertrophy Signaling
- Glucocorticoid Receptor Signaling
- CD40 Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- Corticotropin Releasing Hormone Signaling
- CCR3 Signaling in Eosinophils
- NRF2-mediated Oxidative Stress Response
- IL-6 Signaling
- Thrombin Signaling
- LPS-stimulated MAPK Signaling
- CCR5 Signaling in Macrophages
- GNRH Signaling
- IL-10 Signaling
- IL-22 Signaling
- HIF1α Signaling
- April Mediated Signaling
- Leukocyte Extravasation Signaling
- Type I Diabetes Mellitus Signaling
- Chemokine Signaling
- B Cell Receptor Signaling
- Toll-like Receptor Signaling
- Xenobiotic Metabolism Signaling
- RAR Activation
- Cdc42 Signaling
- AMPK Signaling
- Parkinson's Signaling
- p38 MAPK Signaling
Protein Domains
ATP binding, kinase, MAP kinase, MAP kinase kinase, MP kinase, protein binding, protein C-terminus binding, Protein kinase, protein serine/threonine kinase, SH3 domain
Subcellular Locations
C fiber, cell cortex, cytoplasm, cytosol, cytosolic fraction, focal adhesions, mitochondria, neurites, nuclear fraction, nucleus, perinuclear region
