POLS - polymerase (DNA directed) sigma
Entrez Gene Name: polymerase (DNA directed) sigma
Entrez GeneID: Human(11044)
, Mouse(210106), Rat(306672)
, Mouse(210106), Rat(306672) Synonyms: DNA repair, LAK-1, MGC69673, POLK, POLS, POLYMERASE SIGMA, TRF4, TRF4-1
Gene Summary
- Human (11044): The protein encoded by this gene is a DNA polymerase that is likely involved in DNA repair. In addition, the encoded protein may be required for sister chromatid adhesion. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Regulates:
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Biological Process
cell cycle, cell division, DNA replication, double-strand break repair, mitosis, mitotic chromosome condensation, response to drug, sister chromatid cohesion
Literature References
- 17554300Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.Nature 2007 06 7;447(7145):661-78
- 18256032Stoecklin G, Tenenbaum SA, Mayo T, Chittur SV, George AD, Baroni TE, Blackshear PJ, Anderson P. Genome-wide Analysis Identifies Interleukin-10 mRNA as Target of Tristetraprolin.J Biol Chem 2008 Apr 25;283(17):11689-99
- 17303664Almon RR, Dubois DC, Jusko WJ. A microarray analysis of the temporal response of liver to methylprednisolone: a comparative analysis of two dosing regimens.Endocrinology 2007 May 01;148(5):2209-25 View 9 categorized literature findings and their references in IPA
Molecular Functions
DNA binding, DNA-directed DNA polymerase activity, nucleotidyltransferase activity, SMC protein binding, transferase activity
Protein Domains
DNA-directed DNA polymerase, enzyme, nucleotidyltransferase domain, PAP/25A associated domain
