NOS1 - nitric oxide synthase 1 (neuronal)
Entrez Gene Name: nitric oxide synthase 1 (neuronal)
Entrez GeneID: Human(4842)
, Mouse(18125), Rat(24598)
, Mouse(18125), Rat(24598) Synonyms: 2310005C01RIK, BNOS, IHPS1, mtNOS, Neuronal no synthase, Nitric oxide synthetase, NNOS, nNOS-2, NO, NOS, NOS-I, NOS1
Gene Summary
- Human (4842): Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. This gene encodes a nitric oxide synthase which is highly expressed in skeletal muscle. Genetic variations in this gene are associated with infantile hypertrophic pyloric stenosis type 1.
- Rat (24598): enzyme that catalyzes the production of nitric oxide [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
aging, arginine catabolic process, exogenous drug catabolic process, multicellular organismal response to stress, myoblast fusion, negative regulation of blood pressure, negative regulation of calcium ion transport, negative regulation of calcium ion transport into cytosol, negative regulation of heart contraction, negative regulation of hydrolase activity, negative regulation of insulin secretion, negative regulation of potassium ion transport, neurotransmitter biosynthetic process, nitric oxide biosynthetic process, oxidation reduction, peptidyl-cysteine S-nitrosylation, positive regulation of vasodilation, regulation of cardiac muscle contraction, regulation of heart contraction, regulation of sensory perception of pain, regulation of sodium ion transport, response to estrogen stimulus, response to ethanol, response to heat, response to hypoxia, response to organic cyclic substance, response to organic nitrogen, response to vitamin E, striated muscle contraction
Cellular Components
azurophil granule, cell projection, cytoplasm, cytoskeleton, cytosol, dendrite, dendritic spine, membrane, mitochondrial outer membrane, mitochondrion, nuclear membrane, nucleus, perinuclear region of cytoplasm, photoreceptor inner segment, plasma membrane, sarcolemma, sarcoplasmic reticulum, synapse
Literature References
- 11086993Fang M, Jaffrey SR, Sawa A, Ye K, Luo X, Snyder SH. Dexras1: a G protein specifically coupled to neuronal nitric oxide synthase via CAPON.Neuron 2000 Oct 1;28(1):183-93
- 8625413Brenman JE, Chao DS, Gee SH, McGee AW, Craven SE, Santillano DR, Wu Z, Huang F, Xia H, Peters MF, Froehner SC, Bredt DS. Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains.Cell 1996 Mar 8;84(5):757-67
- 18007024Zhang YH, Zhang MH, Sears CE, Emanuel K, Redwood C, El-Armouche A, Kranias EG, Casadei B. Reduced phospholamban phosphorylation is associated with impaired relaxation in left ventricular myocytes from neuronal NO synthase-deficient mice.Circ Res 2008 Feb 01;102(2):242-9 View 2740 categorized literature findings and their references in IPA
Molecular Functions
amino acid binding, arginine binding, cadmium ion binding, calmodulin binding, electron carrier activity, enzyme binding, FAD binding, FMN binding, heme binding, iron ion binding, metal ion binding, NADP or NADPH binding, nitric-oxide synthase activity, oxidoreductase activity, protein binding, protein homodimerization activity, tetrahydrobiopterin binding
Protein Domains
amino acid binding, cadmium ion binding, calmodulin binding, enzyme, enzyme binding, FAD binding, FAD binding domain, FMN binding, heme binding, NAD binding domain, NADPH binding, Nitric-oxide synthase, oxygenase domain, pdz domain, protein binding, protein homodimerization, reductase domain
Subcellular Locations
axons, caveolae, cell body, cellular membrane, costameres, cytoplasm, cytoplasmic matrix, cytosol, cytosolic fraction, dendrites, detergent-insoluble fractions, detergent-soluble fraction, insoluble fractions, membrane fraction, membrane processes, membrane rafts, microsome, myotendinous junctions, neurites, nuclear fraction, nucleus, plasma membrane, plasma membrane fraction, postsynaptic density, postsynaptic density (PSD) fractions, postsynaptic membrane, sarcolemma, soluble fraction, synapse, synaptic plasma membrane fractions, synaptic vesicles, synaptosomes
